Interleukin-1 receptor accessory protein-like 1
Intermolecular
Cysteine 99 of Tumor suppressor candidate 3 and cysteine 216
Intramolecular
Cysteine 31 and cysteine 126
Cysteine 143 and cysteine 185
Cysteine 164 and cysteine 216
Cysteine 267 and cysteine 334
Cysteine 53 and cysteine 118
Cysteine 512 and cysteine 544
4m92 A 58 B 10
A redox-regulated disulphide may form between cysteine 99 of Tumor suppressor candidate 3 and cysteine 216 of Interleukin-1 receptor accessory protein-like 1 (58 and 10 respectively in this structure).
Details
Redox score ?
88
PDB code
4m92
Structure name
crystal structure of hn33/tusc3-peptide 2
Structure deposition date
2013-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tumor suppressor candidate 3
Peptide B name
Interleukin-1 receptor accessory protein-like 1
Peptide A accession
Q13454
Peptide B accession
Q9NZN1
Peptide A residue number
99
Peptide B residue number
216
Ligandability
Cysteine 99 of Tumor suppressor candidate 3
Cysteine 216 of Interleukin-1 receptor accessory protein-like 1
5wy8 B 31 B 126
A redox-regulated disulphide may form within Interleukin-1 receptor accessory protein-like 1 between cysteines 31 and 126.
Details
Redox score ?
87
PDB code
5wy8
Structure name
crystal structure of ptp delta ig1-ig3 in complex with il1rapl1 ig1- ig3
Structure deposition date
2017-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZN1
Residue number A
31
Residue number B
126
Peptide name
Interleukin-1 receptor accessory protein-like 1
Ligandability
Cysteine 31 of Interleukin-1 receptor accessory protein-like 1
Cysteine 126 of Interleukin-1 receptor accessory protein-like 1
5wy8 B 143 B 185
A redox-regulated disulphide may form within Interleukin-1 receptor accessory protein-like 1 between cysteines 143 and 185.
Details
Redox score ?
84
PDB code
5wy8
Structure name
crystal structure of ptp delta ig1-ig3 in complex with il1rapl1 ig1- ig3
Structure deposition date
2017-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZN1
Residue number A
143
Residue number B
185
Peptide name
Interleukin-1 receptor accessory protein-like 1
Ligandability
Cysteine 143 of Interleukin-1 receptor accessory protein-like 1
Cysteine 185 of Interleukin-1 receptor accessory protein-like 1
5wy8 B 164 B 216
A redox-regulated disulphide may form within Interleukin-1 receptor accessory protein-like 1 between cysteines 164 and 216.
Details
Redox score ?
82
PDB code
5wy8
Structure name
crystal structure of ptp delta ig1-ig3 in complex with il1rapl1 ig1- ig3
Structure deposition date
2017-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZN1
Residue number A
164
Residue number B
216
Peptide name
Interleukin-1 receptor accessory protein-like 1
Ligandability
Cysteine 164 of Interleukin-1 receptor accessory protein-like 1
Cysteine 216 of Interleukin-1 receptor accessory protein-like 1
5wy8 B 267 B 334
A redox-regulated disulphide may form within Interleukin-1 receptor accessory protein-like 1 between cysteines 267 and 334.
Details
Redox score ?
80
PDB code
5wy8
Structure name
crystal structure of ptp delta ig1-ig3 in complex with il1rapl1 ig1- ig3
Structure deposition date
2017-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZN1
Residue number A
267
Residue number B
334
Peptide name
Interleukin-1 receptor accessory protein-like 1
Ligandability
Cysteine 267 of Interleukin-1 receptor accessory protein-like 1
Cysteine 334 of Interleukin-1 receptor accessory protein-like 1
5wy8 B 53 B 118
A redox-regulated disulphide may form within Interleukin-1 receptor accessory protein-like 1 between cysteines 53 and 118.
Details
Redox score ?
79
PDB code
5wy8
Structure name
crystal structure of ptp delta ig1-ig3 in complex with il1rapl1 ig1- ig3
Structure deposition date
2017-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZN1
Residue number A
53
Residue number B
118
Peptide name
Interleukin-1 receptor accessory protein-like 1
Ligandability
Cysteine 53 of Interleukin-1 receptor accessory protein-like 1
Cysteine 118 of Interleukin-1 receptor accessory protein-like 1
1t3g B 512 B 544
A redox-regulated disulphide may form within Interleukin-1 receptor accessory protein-like 1 between cysteines 512 and 544. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
1t3g
Structure name
crystal structure of the toll/interleukin-1 receptor (tir) domain of human il-1rapl
Structure deposition date
2004-04-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
52
Peptide accession
Q9NZN1
Residue number A
512
Residue number B
544
Peptide name
Interleukin-1 receptor accessory protein-like 1
Ligandability
Cysteine 512 of Interleukin-1 receptor accessory protein-like 1
Cysteine 544 of Interleukin-1 receptor accessory protein-like 1
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