ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Aryl-hydrocarbon-interacting protein-like 1

Intramolecular
Cysteine 42 and cysteine 89
Cysteine 237 and cysteine 239
A redox-regulated disulphide may form within Aryl-hydrocarbon-interacting protein-like 1 between cysteines 42 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5u9k
Structure name
crystal structure of v71f mutant of the fkbp domain of human aryl hydrocarbon receptor-interacting protein-like 1 (aipl1)
Structure deposition date
2016-12-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
47
Peptide accession
Q9NZN9
Residue number A
42
Residue number B
89
Peptide name
Aryl-hydrocarbon-interacting protein-like 1

Ligandability

Cysteine 42 of Aryl-hydrocarbon-interacting protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Aryl-hydrocarbon-interacting protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aryl-hydrocarbon-interacting protein-like 1 between cysteines 237 and 239. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6px0
Structure name
crystal structure of the tpr domain of human aryl hydrocarbon receptor-interacting protein-like 1 (aipl1)
Structure deposition date
2019-07-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
74
Peptide accession
Q9NZN9
Residue number A
237
Residue number B
239
Peptide name
Aryl-hydrocarbon-interacting protein-like 1

Ligandability

Cysteine 237 of Aryl-hydrocarbon-interacting protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Aryl-hydrocarbon-interacting protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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