ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Leucine-rich repeat transmembrane protein FLRT3

Intramolecular
Cysteine 31 and cysteine 37
Cysteine 309 and cysteine 334
Cysteine 35 and cysteine 44
Cysteine 35 and cysteine 37
Cysteine 37 and cysteine 44
Cysteine 31 and cysteine 35
Cysteine 31 and cysteine 44
A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 31 and 37.

Details

Redox score ?
89
PDB code
5cmp
Structure name
human flrt3 lrr domain
Structure deposition date
2015-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZU0
Residue number A
31
Residue number B
37
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 31 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 309 and 334.

Details

Redox score ?
85
PDB code
6jbu
Structure name
high resolution crystal structure of human flrt3 lrr domain in complex with mouse cirl3 olfactomedin like domain
Structure deposition date
2019-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZU0
Residue number A
309
Residue number B
334
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 309 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 35 and 44.

Details

Redox score ?
82
PDB code
5cmn
Structure name
flrt3 lrr domain in complex with lphn3 olfactomedin domain
Structure deposition date
2015-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZU0
Residue number A
35
Residue number B
44
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 35 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 35 and 37.

Details

Redox score ?
66
PDB code
4v2e
Structure name
flrt3 lrr domain
Structure deposition date
2014-10-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BGT1
Residue number A
35
Residue number B
37
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 35 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 37 and 44.

Details

Redox score ?
62
PDB code
5cmp
Structure name
human flrt3 lrr domain
Structure deposition date
2015-07-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZU0
Residue number A
37
Residue number B
44
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 37 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 31 and 35. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5cmn
Structure name
flrt3 lrr domain in complex with lphn3 olfactomedin domain
Structure deposition date
2015-07-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZU0
Residue number A
31
Residue number B
35
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 31 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 35 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucine-rich repeat transmembrane protein FLRT3 between cysteines 31 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5cmn
Structure name
flrt3 lrr domain in complex with lphn3 olfactomedin domain
Structure deposition date
2015-07-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZU0
Residue number A
31
Residue number B
44
Peptide name
Leucine-rich repeat transmembrane protein FLRT3

Ligandability

Cysteine 31 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of Leucine-rich repeat transmembrane protein FLRT3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: