Potassium voltage-gated channel subfamily D member 2
Intermolecular
Cysteine 133 and cysteine 111
Cysteine 111 and cysteine 132
Cysteine 107 of Dipeptidyl aminopeptidase-like protein 6 and cysteine 236
Cysteine 236 and cysteine 43 of Dipeptidyl-peptidase 6
Intramolecular
Cysteine 209 and cysteine 221
Cysteine 132 and cysteine 133
Cysteine 320 and cysteine 406
7e87 B 133 D 111
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily D member 2 at cysteines 133 and 111.
Details
Redox score ?
82
PDB code
7e87
Structure name
cryoem structure of the human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
3
% buried
100
Peptide A name
Potassium voltage-gated channel subfamily D member 2
Peptide B name
Potassium voltage-gated channel subfamily D member 2
Peptide A accession
Q9NZV8
Peptide B accession
Q9NZV8
Peptide A residue number
133
Peptide B residue number
111
Ligandability
Cysteine 133 of Potassium voltage-gated channel subfamily D member 2
Cysteine 111 of Potassium voltage-gated channel subfamily D member 2
7e8b B 111 A 132
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily D member 2 at cysteines 111 and 132.
Details
Redox score ?
63
PDB code
7e8b
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
86
Peptide A name
Potassium voltage-gated channel subfamily D member 2
Peptide B name
Potassium voltage-gated channel subfamily D member 2
Peptide A accession
Q9NZV8
Peptide B accession
Q9NZV8
Peptide A residue number
111
Peptide B residue number
132
Ligandability
Cysteine 111 of Potassium voltage-gated channel subfamily D member 2
Cysteine 132 of Potassium voltage-gated channel subfamily D member 2
7e8h J 45 B 236
A redox-regulated disulphide may form between cysteine 107 of Dipeptidyl aminopeptidase-like protein 6 and cysteine 236 of Potassium voltage-gated channel subfamily D member 2 (45 and 236 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7e8h
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
47
Peptide A name
Dipeptidyl aminopeptidase-like protein 6
Peptide B name
Potassium voltage-gated channel subfamily D member 2
Peptide A accession
P42658
Peptide B accession
Q9NZV8
Peptide A residue number
107
Peptide B residue number
236
Ligandability
Cysteine 107 of Dipeptidyl aminopeptidase-like protein 6
Cysteine 236 of Potassium voltage-gated channel subfamily D member 2
7ukg B 236 J 107
A redox-regulated disulphide may form between cysteine 236 of Potassium voltage-gated channel subfamily D member 2 and cysteine 43 of Dipeptidyl-peptidase 6 (236 and 107 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7ukg
Structure name
human kv4
Structure deposition date
2022-04-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
51
Peptide A name
Potassium voltage-gated channel subfamily D member 2
Peptide B name
Dipeptidyl-peptidase 6
Peptide A accession
Q9NZV8
Peptide B accession
A7E2E4
Peptide A residue number
236
Peptide B residue number
43
Ligandability
Cysteine 236 of Potassium voltage-gated channel subfamily D member 2
Cysteine 43 of Dipeptidyl-peptidase 6
7uk5 A 209 A 221
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 2 between cysteines 209 and 221.
Details
Redox score ?
81
PDB code
7uk5
Structure name
human kv4
Structure deposition date
2022-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
4
Peptide accession
Q9NZV8
Residue number A
209
Residue number B
221
Peptide name
Potassium voltage-gated channel subfamily D member 2
Ligandability
Cysteine 209 of Potassium voltage-gated channel subfamily D member 2
Cysteine 221 of Potassium voltage-gated channel subfamily D member 2
1nn7 A 132 A 133
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 2 between cysteines 132 and 133.
Details
Redox score ?
80
PDB code
1nn7
Structure name
crystal structure of the tetramerization domain of the shal voltage- gated potassium channel
Structure deposition date
2003-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
6
Peptide accession
Q63881
Residue number A
132
Residue number B
133
Peptide name
Potassium voltage-gated channel subfamily D member 2
Ligandability
Cysteine 132 of Potassium voltage-gated channel subfamily D member 2
Cysteine 133 of Potassium voltage-gated channel subfamily D member 2
7ukf B 320 B 406
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 2 between cysteines 320 and 406.
Details
Redox score ?
nan
PDB code
7ukf
Structure name
human kv4
Structure deposition date
2022-04-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
0
% buried
84
Peptide accession
Q9NZV8
Residue number A
320
Residue number B
406
Peptide name
Potassium voltage-gated channel subfamily D member 2
Ligandability
Cysteine 320 of Potassium voltage-gated channel subfamily D member 2
Cysteine 406 of Potassium voltage-gated channel subfamily D member 2
Cysteine 406 in protein B could not be asigned to a Uniprot residue.
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