ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cysteine-rich PDZ-binding protein

Intramolecular
Cysteine 58 and cysteine 61
Cysteine 3 and cysteine 6
Cysteine 58 and cysteine 76
Cysteine 58 and cysteine 73
Cysteine 3 and cysteine 86
Cysteine 61 and cysteine 73
Cysteine 3 and cysteine 83
Cysteine 61 and cysteine 76
Cysteine 6 and cysteine 83
Cysteine 6 and cysteine 86
More...
Cysteine 83 and cysteine 86
Cysteine 73 and cysteine 76
A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 58 and 61.

Details

Redox score ?
87
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
6
% buried
24
Peptide accession
Q9P021
Residue number A
58
Residue number B
61
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 58 of Cysteine-rich PDZ-binding protein

Cysteine 61 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 3 and 6.

Details

Redox score ?
85
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
30
Peptide accession
Q9P021
Residue number A
3
Residue number B
6
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 3 of Cysteine-rich PDZ-binding protein

Cysteine 6 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 58 and 76.

Details

Redox score ?
82
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
34
Peptide accession
Q9P021
Residue number A
58
Residue number B
76
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 58 of Cysteine-rich PDZ-binding protein

Cysteine 76 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 58 and 73.

Details

Redox score ?
82
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
42
Peptide accession
Q9P021
Residue number A
58
Residue number B
73
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 58 of Cysteine-rich PDZ-binding protein

Cysteine 73 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 3 and 86.

Details

Redox score ?
81
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
26
Peptide accession
Q9P021
Residue number A
3
Residue number B
86
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 3 of Cysteine-rich PDZ-binding protein

Cysteine 86 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 61 and 73.

Details

Redox score ?
78
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
40
Peptide accession
Q9P021
Residue number A
61
Residue number B
73
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 61 of Cysteine-rich PDZ-binding protein

Cysteine 73 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 3 and 83.

Details

Redox score ?
78
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
6
% buried
45
Peptide accession
Q9P021
Residue number A
3
Residue number B
83
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 3 of Cysteine-rich PDZ-binding protein

Cysteine 83 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 61 and 76.

Details

Redox score ?
77
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
31
Peptide accession
Q9P021
Residue number A
61
Residue number B
76
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 61 of Cysteine-rich PDZ-binding protein

Cysteine 76 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 6 and 83.

Details

Redox score ?
76
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
48
Peptide accession
Q9P021
Residue number A
6
Residue number B
83
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 6 of Cysteine-rich PDZ-binding protein

Cysteine 83 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 6 and 86.

Details

Redox score ?
75
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
28
Peptide accession
Q9P021
Residue number A
6
Residue number B
86
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 6 of Cysteine-rich PDZ-binding protein

Cysteine 86 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 83 and 86.

Details

Redox score ?
73
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
44
Peptide accession
Q9P021
Residue number A
83
Residue number B
86
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 83 of Cysteine-rich PDZ-binding protein

Cysteine 86 of Cysteine-rich PDZ-binding protein

A redox-regulated disulphide may form within Cysteine-rich PDZ-binding protein between cysteines 73 and 76.

Details

Redox score ?
67
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
50
Peptide accession
Q9P021
Residue number A
73
Residue number B
76
Peptide name
Cysteine-rich PDZ-binding protein

Ligandability

Cysteine 73 of Cysteine-rich PDZ-binding protein

Cysteine 76 of Cysteine-rich PDZ-binding protein

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