a tool for identifying drug-targetable redox-active disulphides

Mediator of RNA polymerase II transcription subunit 11

Intermolecular

Cysteine 90 and cysteine 112 of Mediator of RNA polymerase II transcription subunit 22 L

A redox-regulated disulphide may form between cysteine 90 of Mediator of RNA polymerase II transcription subunit 11 and cysteine 112 of Mediator of RNA polymerase II transcription subunit 22. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

49

PDB code

Structure name

human mediator with rna polymerase ii pre-initiation complex

Structure deposition date

2021-03-15

Thiol separation (Å)

8

Half-sphere exposure sum ?

61

Minimum pK_a ?

11

% buried

70

Peptide A name

Mediator of RNA polymerase II transcription subunit 11

Peptide B name

Mediator of RNA polymerase II transcription subunit 22

Peptide A accession

Peptide B accession

Peptide A residue number

90

Peptide B residue number

112

Ligandability

Cysteine 90 of Mediator of RNA polymerase II transcription subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Mediator of RNA polymerase II transcription subunit 22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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