ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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39S ribosomal protein L36, mitochondrial

Intramolecular
Cysteine 76 and cysteine 92
Cysteine 79 and cysteine 92
Cysteine 76 and cysteine 79
A redox-regulated disulphide may form within 39S ribosomal protein L36, mitochondrial between cysteines 76 and 92.

Details

Redox score ?
84
PDB code
7qh7
Structure name
cryo-em structure of the human mtlsu assembly intermediate upon mrm2 depletion - class 4
Structure deposition date
2021-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
10
Peptide accession
Q9P0J6
Residue number A
76
Residue number B
92
Peptide name
39S ribosomal protein L36, mitochondrial

Ligandability

Cysteine 76 of 39S ribosomal protein L36, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of 39S ribosomal protein L36, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein L36, mitochondrial between cysteines 79 and 92.

Details

Redox score ?
81
PDB code
7of0
Structure name
structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with mterf4-nsun4 (dataset1)
Structure deposition date
2021-05-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
44
Peptide accession
Q9P0J6
Residue number A
79
Residue number B
92
Peptide name
39S ribosomal protein L36, mitochondrial

Ligandability

Cysteine 79 of 39S ribosomal protein L36, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of 39S ribosomal protein L36, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein L36, mitochondrial between cysteines 76 and 79.

Details

Redox score ?
81
PDB code
3j7y
Structure name
structure of the large ribosomal subunit from human mitochondria
Structure deposition date
2014-08-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
40
Minimum pKa ?
10
% buried
42
Peptide accession
Q9P0J6
Residue number A
76
Residue number B
79
Peptide name
39S ribosomal protein L36, mitochondrial

Ligandability

Cysteine 76 of 39S ribosomal protein L36, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of 39S ribosomal protein L36, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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