ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polycystic kidney disease 2-like 1 protein

Intramolecular
Cysteine 210 and cysteine 223
Cysteine 115 and cysteine 355
A redox-regulated disulphide may form within Polycystic kidney disease 2-like 1 protein between cysteines 210 and 223.

Details

Redox score ?
80
PDB code
6du8
Structure name
human polycsytin 2-l1
Structure deposition date
2018-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
48
Peptide accession
Q9P0L9
Residue number A
210
Residue number B
223
Peptide name
Polycystic kidney disease 2-like 1 protein

Ligandability

Cysteine 210 of Polycystic kidney disease 2-like 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Polycystic kidney disease 2-like 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycystic kidney disease 2-like 1 protein between cysteines 115 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7d7e
Structure name
structure of pkd1l3-ctd/pkd2l1 in apo state
Structure deposition date
2020-10-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
30
Peptide accession
A2A259
Residue number A
115
Residue number B
355
Peptide name
Polycystic kidney disease 2-like 1 protein

Ligandability

Cysteine 115 of Polycystic kidney disease 2-like 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of Polycystic kidney disease 2-like 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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