a tool for identifying drug-targetable redox-active disulphides

Core histone macro-H2A.2

Intramolecular

Cysteine 276 and cysteine 297 L

A redox-regulated disulphide may form within Core histone macro-H2A.2 between cysteines 276 and 297.

Details

Redox score ?

70

PDB code

Structure name

crystal structure of the macro domain of human macroh2a2

Structure deposition date

2018-03-10

Thiol separation (Å)

4

Half-sphere exposure sum ?

85

Minimum pK_a ?

9

% buried

100

Peptide accession

Residue number A

276

Residue number B

297

Peptide name

Core histone macro-H2A

Ligandability

Cysteine 276 of Core histone macro-H2A.2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Core histone macro-H2A.2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: