ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TBC1 domain family member 7

Intramolecular
Cysteine 210 and cysteine 232
Cysteine 232 and cysteine 286
Cysteine 210 and cysteine 214
A redox-regulated disulphide may form within TBC1 domain family member 7 between cysteines 210 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5ejc
Structure name
crystal structural of the tsc1-tbc1d7 complex
Structure deposition date
2015-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
81
Peptide accession
Q9P0N9
Residue number A
210
Residue number B
232
Peptide name
TBC1 domain family member 7

Ligandability

Cysteine 210 of TBC1 domain family member 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of TBC1 domain family member 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TBC1 domain family member 7 between cysteines 232 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3qwl
Structure name
crystal structure of human tbc1 domain family member 7
Structure deposition date
2011-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0N9
Residue number A
232
Residue number B
286
Peptide name
TBC1 domain family member 7

Ligandability

Cysteine 232 of TBC1 domain family member 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of TBC1 domain family member 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TBC1 domain family member 7 between cysteines 210 and 214. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7dl2
Structure name
cryo-em structure of human tsc complex
Structure deposition date
2020-11-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
90
Peptide accession
Q9P0N9
Residue number A
210
Residue number B
214
Peptide name
TBC1 domain family member 7

Ligandability

Cysteine 210 of TBC1 domain family member 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of TBC1 domain family member 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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