ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sentrin-specific protease 1

Intramolecular
Cysteine 535 and cysteine 603
Cysteine 603 and cysteine 608
A redox-regulated disulphide may form within Sentrin-specific protease 1 between cysteines 535 and 603 (535 and 602 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6nnq
Structure name
non-covalent structure of senp1 in complex with sumo2
Structure deposition date
2019-01-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
84
Peptide accession
Q9P0U3
Residue number A
535
Residue number B
603
Peptide name
Sentrin-specific protease 1

Ligandability

Cysteine 535 of Sentrin-specific protease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 603 of Sentrin-specific protease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sentrin-specific protease 1 between cysteines 603 and 608 (602 and 607 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2ckg
Structure name
the structure of senp1 sumo-2 co-complex suggests a structural basis for discrimination between sumo paralogues during processing
Structure deposition date
2006-04-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
98
Peptide accession
Q9P0U3
Residue number A
603
Residue number B
608
Peptide name
Sentrin-specific protease 1

Ligandability

Cysteine 603 of Sentrin-specific protease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Sentrin-specific protease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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