ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CXXC-type zinc finger protein 1

Intramolecular
Cysteine 175 and cysteine 208
Cysteine 172 and cysteine 175
Cysteine 169 and cysteine 208
Cysteine 181 and cysteine 184
Cysteine 181 and cysteine 203
Cysteine 172 and cysteine 208
Cysteine 169 and cysteine 172
Cysteine 181 and cysteine 187
Cysteine 184 and cysteine 187
Cysteine 169 and cysteine 175
More...
Cysteine 184 and cysteine 203
Cysteine 187 and cysteine 203
A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 175 and 208.

Details

Redox score ?
89
PDB code
3qmg
Structure name
structural basis of selective binding of non-methylated cpg islands by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
5
% buried
0
Peptide accession
Q9P0U4
Residue number A
175
Residue number B
208
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 175 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 172 and 175.

Details

Redox score ?
89
PDB code
3qmh
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-tcga) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
43
Minimum pKa ?
6
% buried
0
Peptide accession
Q9P0U4
Residue number A
172
Residue number B
175
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 172 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 169 and 208.

Details

Redox score ?
88
PDB code
3qmg
Structure name
structural basis of selective binding of non-methylated cpg islands by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
5
% buried
0
Peptide accession
Q9P0U4
Residue number A
169
Residue number B
208
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 169 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 181 and 184.

Details

Redox score ?
87
PDB code
3qmh
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-tcga) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
13
Peptide accession
Q9P0U4
Residue number A
181
Residue number B
184
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 181 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 181 and 203.

Details

Redox score ?
87
PDB code
3qmh
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-tcga) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
5
% buried
12
Peptide accession
Q9P0U4
Residue number A
181
Residue number B
203
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 181 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 172 and 208 (176 and 212 respectively in this structure).

Details

Redox score ?
86
PDB code
3qmb
Structure name
structural basis of selective binding of nonmethylated cpg islands by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
5
% buried
0
Peptide accession
Q9P0U4
Residue number A
172
Residue number B
208
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 172 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 169 and 172.

Details

Redox score ?
85
PDB code
3qmi
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-acgt) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide accession
Q9P0U4
Residue number A
169
Residue number B
172
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 169 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 181 and 187.

Details

Redox score ?
83
PDB code
3qmi
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-acgt) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
8
Peptide accession
Q9P0U4
Residue number A
181
Residue number B
187
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 181 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 184 and 187.

Details

Redox score ?
82
PDB code
3qmh
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-tcga) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
22
Peptide accession
Q9P0U4
Residue number A
184
Residue number B
187
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 184 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 169 and 175 (173 and 179 respectively in this structure).

Details

Redox score ?
78
PDB code
3qmb
Structure name
structural basis of selective binding of nonmethylated cpg islands by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
2
Peptide accession
Q9P0U4
Residue number A
169
Residue number B
175
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 169 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 184 and 203 (188 and 207 respectively in this structure).

Details

Redox score ?
78
PDB code
3qmc
Structure name
structural basis of selective binding of nonmethylated cpg islands by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
27
Peptide accession
Q9P0U4
Residue number A
184
Residue number B
203
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 184 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 1 between cysteines 187 and 203.

Details

Redox score ?
77
PDB code
3qmh
Structure name
structural basis of selective binding of non-methylated cpg islands (dna-tcga) by the cxxc domain of cfp1
Structure deposition date
2011-02-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
22
Peptide accession
Q9P0U4
Residue number A
187
Residue number B
203
Peptide name
CXXC-type zinc finger protein 1

Ligandability

Cysteine 187 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of CXXC-type zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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