ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent T-type calcium channel subunit alpha-1I

Intramolecular
Cysteine 1691 and cysteine 1698
Cysteine 1646 and cysteine 1652
Cysteine 1335 and cysteine 1349
Cysteine 239 and cysteine 280
Cysteine 269 and cysteine 326
Cysteine 280 and cysteine 326
Cysteine 216 and cysteine 393
Cysteine 269 and cysteine 280
Cysteine 239 and cysteine 326
Cysteine 239 and cysteine 269
More...
Cysteine 102 and cysteine 786
Cysteine 1313 and cysteine 1314
A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 1691 and 1698.

Details

Redox score ?
89
PDB code
7wll
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
1691
Residue number B
1698
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 1691 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1698 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 1646 and 1652.

Details

Redox score ?
89
PDB code
7wli
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
1646
Residue number B
1652
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 1646 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1652 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 1335 and 1349.

Details

Redox score ?
87
PDB code
7wlk
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
1335
Residue number B
1349
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 1335 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1349 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 239 and 280.

Details

Redox score ?
84
PDB code
7wli
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
239
Residue number B
280
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 239 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 269 and 326.

Details

Redox score ?
82
PDB code
7wli
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
269
Residue number B
326
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 269 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 280 and 326.

Details

Redox score ?
76
PDB code
7wlk
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
280
Residue number B
326
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 280 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 216 and 393.

Details

Redox score ?
68
PDB code
7wli
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
92
Peptide accession
Q9P0X4
Residue number A
216
Residue number B
393
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 216 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 269 and 280.

Details

Redox score ?
68
PDB code
7wlk
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
269
Residue number B
280
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 269 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 239 and 326.

Details

Redox score ?
67
PDB code
7wli
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
239
Residue number B
326
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 239 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 239 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7wll
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9P0X4
Residue number A
239
Residue number B
269
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 239 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 102 and 786. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7wlj
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
16
Peptide accession
Q9P0X4
Residue number A
102
Residue number B
786
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 102 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 786 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1I between cysteines 1313 and 1314. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7wlk
Structure name
cryoem structure of human low-voltage activated t-type calcium channel cav3
Structure deposition date
2022-01-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
11
% buried
72
Peptide accession
Q9P0X4
Residue number A
1313
Residue number B
1314
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1I

Ligandability

Cysteine 1313 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1314 of Voltage-dependent T-type calcium channel subunit alpha-1I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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