DNA-directed RNA polymerase I subunit RPA12
Intramolecular
Cysteine 87 and cysteine 118
Cysteine 87 and cysteine 90
Cysteine 90 and cysteine 118
Cysteine 87 and cysteine 115
Cysteine 115 and cysteine 118
Cysteine 90 and cysteine 115
Cysteine 23 and cysteine 38
Cysteine 38 and cysteine 41
Cysteine 20 and cysteine 41
Cysteine 20 and cysteine 38
More...Cysteine 23 and cysteine 41
Cysteine 20 and cysteine 23
7oba I 87 I 118
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 87 and 118.
Details
Redox score ?
90
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
0
Peptide accession
Q9P1U0
Residue number A
87
Residue number B
118
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 87 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 118 of DNA-directed RNA polymerase I subunit RPA12
7obb I 87 I 90
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 87 and 90.
Details
Redox score ?
90
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
6
% buried
0
Peptide accession
Q9P1U0
Residue number A
87
Residue number B
90
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 87 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 90 of DNA-directed RNA polymerase I subunit RPA12
7oba I 90 I 118
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 90 and 118.
Details
Redox score ?
87
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
0
Peptide accession
Q9P1U0
Residue number A
90
Residue number B
118
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 90 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 118 of DNA-directed RNA polymerase I subunit RPA12
7oba I 87 I 115
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 87 and 115.
Details
Redox score ?
84
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
0
Peptide accession
Q9P1U0
Residue number A
87
Residue number B
115
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 87 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 115 of DNA-directed RNA polymerase I subunit RPA12
7oba I 115 I 118
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 115 and 118.
Details
Redox score ?
82
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
0
Peptide accession
Q9P1U0
Residue number A
115
Residue number B
118
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 115 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 118 of DNA-directed RNA polymerase I subunit RPA12
7oba I 90 I 115
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 90 and 115.
Details
Redox score ?
82
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
0
Peptide accession
Q9P1U0
Residue number A
90
Residue number B
115
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 90 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 115 of DNA-directed RNA polymerase I subunit RPA12
8a43 I 23 I 38
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 23 and 38.
Details
Redox score ?
77
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
48
Peptide accession
Q9P1U0
Residue number A
23
Residue number B
38
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 23 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 38 of DNA-directed RNA polymerase I subunit RPA12
7oba I 38 I 41
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 38 and 41.
Details
Redox score ?
66
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9P1U0
Residue number A
38
Residue number B
41
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 38 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 41 of DNA-directed RNA polymerase I subunit RPA12
7obb I 20 I 41
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 20 and 41.
Details
Redox score ?
63
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
14
% buried
68
Peptide accession
Q9P1U0
Residue number A
20
Residue number B
41
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 20 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 41 of DNA-directed RNA polymerase I subunit RPA12
7ob9 I 20 I 38
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 20 and 38.
Details
Redox score ?
62
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
15
% buried
nan
Peptide accession
Q9P1U0
Residue number A
20
Residue number B
38
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 20 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 38 of DNA-directed RNA polymerase I subunit RPA12
7oba I 23 I 41
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 23 and 41.
Details
Redox score ?
62
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
14
% buried
75
Peptide accession
Q9P1U0
Residue number A
23
Residue number B
41
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 23 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 41 of DNA-directed RNA polymerase I subunit RPA12
8a43 I 20 I 23
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA12 between cysteines 20 and 23. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
60
Peptide accession
Q9P1U0
Residue number A
20
Residue number B
23
Peptide name
DNA-directed RNA polymerase I subunit RPA12
Ligandability
Cysteine 20 of DNA-directed RNA polymerase I subunit RPA12
Cysteine 23 of DNA-directed RNA polymerase I subunit RPA12
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