ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Intramolecular
Cysteine 1421 and cysteine 1470
Cysteine 1733 and cysteine 1761
Cysteine 1861 and cysteine 1870
A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 between cysteines 1421 and 1470. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6pmp
Structure name
crystal structure of a fragment of rat phospholipase cepsilon ef3-ra1
Structure deposition date
2019-07-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
86
Peptide accession
Q99P84
Residue number A
1421
Residue number B
1470
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Ligandability

Cysteine 1421 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1470 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 between cysteines 1733 and 1761. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6pmp
Structure name
crystal structure of a fragment of rat phospholipase cepsilon ef3-ra1
Structure deposition date
2019-07-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
49
Peptide accession
Q99P84
Residue number A
1733
Residue number B
1761
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Ligandability

Cysteine 1733 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1761 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 between cysteines 1861 and 1870. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6pmp
Structure name
crystal structure of a fragment of rat phospholipase cepsilon ef3-ra1
Structure deposition date
2019-07-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
70
Peptide accession
Q99P84
Residue number A
1861
Residue number B
1870
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Ligandability

Cysteine 1861 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1870 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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