ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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BRCA2 and CDKN1A-interacting protein

Intramolecular
Cysteine 153 and cysteine 157
Cysteine 213 and cysteine 216
A redox-regulated disulphide may form within BRCA2 and CDKN1A-interacting protein between cysteines 153 and 157.

Details

Redox score ?
83
PDB code
7kys
Structure name
crystal structure of human bccip beta (native2)
Structure deposition date
2020-12-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
47
Peptide accession
Q9P287
Residue number A
153
Residue number B
157
Peptide name
BRCA2 and CDKN1A-interacting protein

Ligandability

Cysteine 153 of BRCA2 and CDKN1A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of BRCA2 and CDKN1A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within BRCA2 and CDKN1A-interacting protein between cysteines 213 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7kys
Structure name
crystal structure of human bccip beta (native2)
Structure deposition date
2020-12-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
74
Peptide accession
Q9P287
Residue number A
213
Residue number B
216
Peptide name
BRCA2 and CDKN1A-interacting protein

Ligandability

Cysteine 213 of BRCA2 and CDKN1A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of BRCA2 and CDKN1A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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