a tool for identifying drug-targetable redox-active disulphides

Protocadherin-10

Intramolecular

Cysteine 85 and cysteine 91

A redox-regulated disulphide may form within Protocadherin-10 between cysteines 85 and 91 (68 and 74 respectively in this structure).

Details

Redox score ?

87

PDB code

Structure name

crystal structure of human delta protocadherin 10 ec1-ec4

Structure deposition date

2020-01-06

Thiol separation (Å)

2

Half-sphere exposure sum ?

51

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

85

Residue number B

91

Peptide name

Protocadherin-10

Ligandability

Cysteine 85 of Protocadherin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Protocadherin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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