ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cleavage and polyadenylation specificity factor subunit 2

Intramolecular
Cysteine 577 and cysteine 578
Cysteine 20 and cysteine 34
Cysteine 34 and cysteine 82
A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 2 between cysteines 577 and 578.

Details

Redox score ?
62
PDB code
6v4x
Structure name
cryo-em structure of an active human histone pre-mrna 3'-end processing machinery at 3
Structure deposition date
2019-12-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
42
Peptide accession
Q9P2I0
Residue number A
577
Residue number B
578
Peptide name
Cleavage and polyadenylation specificity factor subunit 2

Ligandability

Cysteine 577 of Cleavage and polyadenylation specificity factor subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Cleavage and polyadenylation specificity factor subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 2 between cysteines 20 and 34. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6v4x
Structure name
cryo-em structure of an active human histone pre-mrna 3'-end processing machinery at 3
Structure deposition date
2019-12-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q9P2I0
Residue number A
20
Residue number B
34
Peptide name
Cleavage and polyadenylation specificity factor subunit 2

Ligandability

Cysteine 20 of Cleavage and polyadenylation specificity factor subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 34 of Cleavage and polyadenylation specificity factor subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 2 between cysteines 34 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6v4x
Structure name
cryo-em structure of an active human histone pre-mrna 3'-end processing machinery at 3
Structure deposition date
2019-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
84
Peptide accession
Q9P2I0
Residue number A
34
Residue number B
82
Peptide name
Cleavage and polyadenylation specificity factor subunit 2

Ligandability

Cysteine 34 of Cleavage and polyadenylation specificity factor subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Cleavage and polyadenylation specificity factor subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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