eIF-2-alpha kinase GCN2

Intramolecular

A redox-regulated disulphide may form within eIF-2-alpha kinase GCN2 between cysteines 614 and 615. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6n3l

Structure name

identification of novel, potent and selective gcn2 inhibitors as first-in-class anti-tumor agents

Structure deposition date

2018-11-15

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q9P2K8

Residue number A

614

Residue number B

615

Peptide name

eIF-2-alpha kinase GCN2

Ligandability

Cysteine 614 of eIF-2-alpha kinase GCN2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.