a tool for identifying drug-targetable redox-active disulphides

TBC1 domain family member 14

Intramolecular

Cysteine 429 and cysteine 499

A redox-regulated disulphide may form within TBC1 domain family member 14 between cysteines 429 and 499 (414 and 484 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

58

PDB code

Structure name

crystal structure of the putative rabgap domain of human tbc1 domain family member 14

Structure deposition date

2007-07-26

Thiol separation (Å)

6

Half-sphere exposure sum ?

58

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

429

Residue number B

499

Peptide name

TBC1 domain family member 14

Ligandability

Cysteine 429 of TBC1 domain family member 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of TBC1 domain family member 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: