a tool for identifying drug-targetable redox-active disulphides

E3 ubiquitin-protein ligase HECW2

Intramolecular

Cysteine 139 and cysteine 156

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase HECW2 between cysteines 139 and 156. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

49

PDB code

Structure name

solution nmr structure of n-terminal domain of human e3 ubiquitin- protein ligase hecw2, northeast structural genomics consortium (nesg) target ht6306a

Structure deposition date

2011-06-29

Thiol separation (Å)

8

Half-sphere exposure sum ?

57

Minimum pK_a ?

9

% buried

27

Peptide accession

Residue number A

139

Residue number B

156

Peptide name

E3 ubiquitin-protein ligase HECW2

Ligandability

Cysteine 139 of E3 ubiquitin-protein ligase HECW2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of E3 ubiquitin-protein ligase HECW2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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