Vesicular glutamate transporter 2
Intramolecular
Cysteine 60 and cysteine 62
Cysteine 62 and cysteine 64
Cysteine 82 and cysteine 89
Cysteine 82 and cysteine 220
Cysteine 321 and cysteine 390
7t3o A 60 A 62
A redox-regulated disulphide may form within Vesicular glutamate transporter 2 between cysteines 60 and 62.
Details
Redox score ?
70
PDB code
7t3o
Structure name
rat vesicular glutamate transporter 2 (vglut2) in low cl condition
Structure deposition date
2021-12-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide accession
Q9JI12
Residue number A
60
Residue number B
62
Peptide name
Vesicular glutamate transporter 2
Ligandability
Cysteine 60 of Vesicular glutamate transporter 2
Cysteine 62 of Vesicular glutamate transporter 2
7t3o A 62 A 64
A redox-regulated disulphide may form within Vesicular glutamate transporter 2 between cysteines 62 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7t3o
Structure name
rat vesicular glutamate transporter 2 (vglut2) in low cl condition
Structure deposition date
2021-12-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
25
Minimum pKa ?
9
% buried
0
Peptide accession
Q9JI12
Residue number A
62
Residue number B
64
Peptide name
Vesicular glutamate transporter 2
Ligandability
Cysteine 62 of Vesicular glutamate transporter 2
Cysteine 64 of Vesicular glutamate transporter 2
7t3o A 82 A 89
A redox-regulated disulphide may form within Vesicular glutamate transporter 2 between cysteines 82 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7t3o
Structure name
rat vesicular glutamate transporter 2 (vglut2) in low cl condition
Structure deposition date
2021-12-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
66
Peptide accession
Q9JI12
Residue number A
82
Residue number B
89
Peptide name
Vesicular glutamate transporter 2
Ligandability
Cysteine 82 of Vesicular glutamate transporter 2
Cysteine 89 of Vesicular glutamate transporter 2
6v4d A 82 A 220
A redox-regulated disulphide may form within Vesicular glutamate transporter 2 between cysteines 82 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6v4d
Structure name
structure of the rat vesicular glutamate transporter 2 determined by single particle cryo-em
Structure deposition date
2019-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
62
Peptide accession
Q9JI12
Residue number A
82
Residue number B
220
Peptide name
Vesicular glutamate transporter 2
Ligandability
Cysteine 82 of Vesicular glutamate transporter 2
Cysteine 220 of Vesicular glutamate transporter 2
6v4d A 321 A 390
A redox-regulated disulphide may form within Vesicular glutamate transporter 2 between cysteines 321 and 390. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6v4d
Structure name
structure of the rat vesicular glutamate transporter 2 determined by single particle cryo-em
Structure deposition date
2019-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
86
Peptide accession
Q9JI12
Residue number A
321
Residue number B
390
Peptide name
Vesicular glutamate transporter 2
Ligandability
Cysteine 321 of Vesicular glutamate transporter 2
Cysteine 390 of Vesicular glutamate transporter 2
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