a tool for identifying drug-targetable redox-active disulphides

Hepatocyte nuclear factor 6

Intramolecular

Cysteine 321 and cysteine 370

A redox-regulated disulphide may form within Hepatocyte nuclear factor 6 between cysteines 321 and 370 (36 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

54

PDB code

Structure name

solution structure of hnf-6

Structure deposition date

2004-01-29

Thiol separation (Å)

8

Half-sphere exposure sum ?

43

Minimum pK_a ?

9

% buried

4

Peptide accession

Residue number A

321

Residue number B

370

Peptide name

Hepatocyte nuclear factor 6

Ligandability

Cysteine 321 of Hepatocyte nuclear factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of Hepatocyte nuclear factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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