a tool for identifying drug-targetable redox-active disulphides

IkB-like protein

Intermolecular

Cysteine 336 of Protein phosphatase 3 catalytic subunit alpha and cysteine 213

A redox-regulated disulphide may form between cysteine 336 of Protein phosphatase 3 catalytic subunit alpha and cysteine 213 of IkB-like protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

42

PDB code

Structure name

crystal structure of calcineurin in complex with the calcineurin- inhibiting domain of the african swine fever virus protein a238l

Structure deposition date

2012-05-05

Thiol separation (Å)

10

Half-sphere exposure sum ?

57

Minimum pK_a ?

10

% buried

39

Peptide A name

Protein phosphatase 3 catalytic subunit alpha

Peptide B name

IkB-like protein

Peptide A accession

Peptide B accession

Peptide A residue number

336

Peptide B residue number

213

Ligandability

Cysteine 336 of Protein phosphatase 3 catalytic subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 213 of IkB-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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