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DNA (cytosine-5)-methyltransferase 3B

Intramolecular
Cysteine 490 and cysteine 527 L
Cysteine 435 and cysteine 455
Cysteine 500 and cysteine 503
Cysteine 435 and cysteine 458
Cysteine 455 and cysteine 458
Cysteine 524 and cysteine 527 L
Cysteine 435 and cysteine 438
Cysteine 478 and cysteine 500
Cysteine 481 and cysteine 503
Cysteine 481 and cysteine 500
More...
Cysteine 495 and cysteine 527 L
Cysteine 438 and cysteine 455
Cysteine 495 and cysteine 524 L
Cysteine 438 and cysteine 458
Cysteine 490 and cysteine 495 L
Cysteine 478 and cysteine 481
Cysteine 481 and cysteine 482
Cysteine 496 and cysteine 527 L
Cysteine 495 and cysteine 496 L
Cysteine 435 and cysteine 481
Cysteine 438 and cysteine 481
Cysteine 490 and cysteine 496 L
Cysteine 490 and cysteine 524 L
Cysteine 435 and cysteine 503
Cysteine 478 and cysteine 503
Cysteine 490 and cysteine 498 L
Cysteine 482 and cysteine 503
Cysteine 478 and cysteine 482
Cysteine 495 and cysteine 498 L
Cysteine 496 and cysteine 498 L
Cysteine 478 and cysteine 498
Cysteine 458 and cysteine 482
Cysteine 458 and cysteine 481
Cysteine 498 and cysteine 524
Cysteine 496 and cysteine 524 L
Cysteine 458 and cysteine 503
A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 490 and 527.

Details

Redox score ?
94
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UBC3
Residue number A
490
Residue number B
527
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 490 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 527 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 435 and 455.

Details

Redox score ?
88
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
5
% buried
0
Peptide accession
Q9UBC3
Residue number A
435
Residue number B
455
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 435 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 455 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 500 and 503.

Details

Redox score ?
87
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
7
Peptide accession
Q9UBC3
Residue number A
500
Residue number B
503
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 500 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 435 and 458.

Details

Redox score ?
83
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
3
% buried
58
Peptide accession
Q9UBC3
Residue number A
435
Residue number B
458
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 435 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 458 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 455 and 458.

Details

Redox score ?
80
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
34
Peptide accession
Q9UBC3
Residue number A
455
Residue number B
458
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 455 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 458 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 524 and 527.

Details

Redox score ?
80
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
73
Peptide accession
Q9UBC3
Residue number A
524
Residue number B
527
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 524 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 435 and 438.

Details

Redox score ?
79
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
3
% buried
50
Peptide accession
Q9UBC3
Residue number A
435
Residue number B
438
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 435 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 438 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 478 and 500.

Details

Redox score ?
78
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
6
% buried
nan
Peptide accession
Q9UBC3
Residue number A
478
Residue number B
500
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 478 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 481 and 503.

Details

Redox score ?
77
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
7
Peptide accession
Q9UBC3
Residue number A
481
Residue number B
503
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 481 and 500.

Details

Redox score ?
77
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
6
% buried
62
Peptide accession
Q9UBC3
Residue number A
481
Residue number B
500
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 495 and 527.

Details

Redox score ?
75
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
62
Peptide accession
Q9UBC3
Residue number A
495
Residue number B
527
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 495 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 527 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 438 and 455.

Details

Redox score ?
75
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
31
Peptide accession
Q9UBC3
Residue number A
438
Residue number B
455
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 438 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 455 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 495 and 524.

Details

Redox score ?
71
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UBC3
Residue number A
495
Residue number B
524
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 495 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 524 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 438 and 458.

Details

Redox score ?
69
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
40
Peptide accession
Q9UBC3
Residue number A
438
Residue number B
458
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 438 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 458 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 490 and 495.

Details

Redox score ?
64
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9UBC3
Residue number A
490
Residue number B
495
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 490 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 495 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 478 and 481.

Details

Redox score ?
63
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9UBC3
Residue number A
478
Residue number B
481
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 478 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 481 and 482. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UBC3
Residue number A
481
Residue number B
482
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 482 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 496 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
54
Peptide accession
Q9UBC3
Residue number A
496
Residue number B
527
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 496 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 527 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 495 and 496. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
80
Peptide accession
Q9UBC3
Residue number A
495
Residue number B
496
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 495 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 496 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 435 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
0
Peptide accession
Q9UBC3
Residue number A
435
Residue number B
481
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 435 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 438 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UBC3
Residue number A
438
Residue number B
481
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 438 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 490 and 496. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UBC3
Residue number A
490
Residue number B
496
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 490 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 496 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 490 and 524. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
22
% buried
nan
Peptide accession
Q9UBC3
Residue number A
490
Residue number B
524
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 490 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 524 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 435 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
3
% buried
78
Peptide accession
Q9UBC3
Residue number A
435
Residue number B
503
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 435 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 478 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
23
% buried
nan
Peptide accession
Q9UBC3
Residue number A
478
Residue number B
503
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 478 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 490 and 498. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
70
Peptide accession
Q9UBC3
Residue number A
490
Residue number B
498
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 490 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 498 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 482 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
7
Peptide accession
Q9UBC3
Residue number A
482
Residue number B
503
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 482 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 478 and 482. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9UBC3
Residue number A
478
Residue number B
482
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 478 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 482 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 495 and 498. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
80
Peptide accession
Q9UBC3
Residue number A
495
Residue number B
498
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 495 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 498 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 496 and 498. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
58
Peptide accession
Q9UBC3
Residue number A
496
Residue number B
498
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 496 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 498 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 478 and 498. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9UBC3
Residue number A
478
Residue number B
498
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 478 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 498 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 458 and 482. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
54
Peptide accession
Q9UBC3
Residue number A
458
Residue number B
482
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 458 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 482 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 458 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
14
% buried
60
Peptide accession
Q9UBC3
Residue number A
458
Residue number B
481
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 458 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 498 and 524. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
76
Peptide accession
Q9UBC3
Residue number A
498
Residue number B
524
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 498 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 524 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 496 and 524. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UBC3
Residue number A
496
Residue number B
524
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 496 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 524 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA (cytosine-5)-methyltransferase 3B between cysteines 458 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
7o45
Structure name
crystal structure of add domain of the human dnmt3b methyltransferase
Structure deposition date
2021-04-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
15
% buried
69
Peptide accession
Q9UBC3
Residue number A
458
Residue number B
503
Peptide name
DNA (cytosine-5)-methyltransferase 3B

Ligandability

Cysteine 458 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of DNA (cytosine-5)-methyltransferase 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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