ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Origin recognition complex subunit 3

Intramolecular
Cysteine 621 and cysteine 630
Cysteine 158 and cysteine 159
Cysteine 418 and cysteine 561
Cysteine 418 and cysteine 475
Cysteine 345 and cysteine 346
Cysteine 418 and cysteine 483 L
Cysteine 440 and cysteine 442
A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 621 and 630. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7jpq
Structure name
orc-o2-5: human origin recognition complex (orc) with subunits 2,3,4,5
Structure deposition date
2020-08-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
62
Peptide accession
Q9UBD5
Residue number A
621
Residue number B
630
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 621 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 630 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 158 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5uj8
Structure name
human origin recognition complex subunits 2 and 3
Structure deposition date
2017-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
39
Peptide accession
Q9UBD5
Residue number A
158
Residue number B
159
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 158 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 418 and 561 (418 and 562 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5uj8
Structure name
human origin recognition complex subunits 2 and 3
Structure deposition date
2017-01-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
14
% buried
96
Peptide accession
Q9UBD5
Residue number A
418
Residue number B
561
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 418 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 561 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 418 and 475. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5uj8
Structure name
human origin recognition complex subunits 2 and 3
Structure deposition date
2017-01-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
96
Peptide accession
Q9UBD5
Residue number A
418
Residue number B
475
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 418 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 345 and 346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5uj8
Structure name
human origin recognition complex subunits 2 and 3
Structure deposition date
2017-01-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UBD5
Residue number A
345
Residue number B
346
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 345 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 418 and 483. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5uj8
Structure name
human origin recognition complex subunits 2 and 3
Structure deposition date
2017-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide accession
Q9UBD5
Residue number A
418
Residue number B
483
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 418 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 483 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 3 between cysteines 440 and 442. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5uj8
Structure name
human origin recognition complex subunits 2 and 3
Structure deposition date
2017-01-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
82
Peptide accession
Q9UBD5
Residue number A
440
Residue number B
442
Peptide name
Origin recognition complex subunit 3

Ligandability

Cysteine 440 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 442 of Origin recognition complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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