ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ammonium transporter Rh type C

Intramolecular
Cysteine 260 and cysteine 313
Cysteine 131 and cysteine 136
A redox-regulated disulphide may form within Ammonium transporter Rh type C between cysteines 260 and 313. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3hd6
Structure name
crystal structure of the human rhesus glycoprotein rhcg
Structure deposition date
2009-05-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
97
Peptide accession
Q9UBD6
Residue number A
260
Residue number B
313
Peptide name
Ammonium transporter Rh type C

Ligandability

Cysteine 260 of Ammonium transporter Rh type C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of Ammonium transporter Rh type C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ammonium transporter Rh type C between cysteines 131 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
20
PDB code
3hd6
Structure name
crystal structure of the human rhesus glycoprotein rhcg
Structure deposition date
2009-05-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
101
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UBD6
Residue number A
131
Residue number B
136
Peptide name
Ammonium transporter Rh type C

Ligandability

Cysteine 131 of Ammonium transporter Rh type C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Ammonium transporter Rh type C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: