RING-box protein 2
Intramolecular
Cysteine 61 and cysteine 64
Cysteine 61 and cysteine 73
Cysteine 50 and cysteine 53
Cysteine 61 and cysteine 87
Cysteine 80 and cysteine 102
Cysteine 53 and cysteine 88
Cysteine 99 and cysteine 102
Cysteine 64 and cysteine 73
Cysteine 80 and cysteine 99
Cysteine 53 and cysteine 61
More...Cysteine 73 and cysteine 87
Cysteine 64 and cysteine 87
Cysteine 50 and cysteine 88
Cysteine 87 and cysteine 88
Cysteine 61 and cysteine 88
Cysteine 50 and cysteine 87
Cysteine 50 and cysteine 73
Cysteine 73 and cysteine 88
Cysteine 53 and cysteine 73
Cysteine 50 and cysteine 61
Cysteine 53 and cysteine 87
Cysteine 50 and cysteine 99
Cysteine 64 and cysteine 88
Cysteine 53 and cysteine 64
Cysteine 47 and cysteine 102
Cysteine 47 and cysteine 99
2ecl A 29 A 32
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 61 and 64 (29 and 32 respectively in this structure).
Details
Redox score ?
89
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
5
% buried
10
Peptide accession
Q9UBF6
Residue number A
61
Residue number B
64
Peptide name
RING-box protein 2
Ligandability
Cysteine 61 of RING-box protein 2
Cysteine 64 of RING-box protein 2
2ecl A 29 A 41
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 61 and 73 (29 and 41 respectively in this structure).
Details
Redox score ?
87
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
5
% buried
19
Peptide accession
Q9UBF6
Residue number A
61
Residue number B
73
Peptide name
RING-box protein 2
Ligandability
Cysteine 61 of RING-box protein 2
Cysteine 73 of RING-box protein 2
6v9i R 50 R 53
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 50 and 53.
Details
Redox score ?
86
PDB code
6v9i
Structure name
cryo-em structure of cullin5 bound to ring-box protein 2 (cul5-rbx2)
Structure deposition date
2019-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WTZ1
Residue number A
50
Residue number B
53
Peptide name
RING-box protein 2
Ligandability
Cysteine 50 of RING-box protein 2
Cysteine 53 of RING-box protein 2
2ecl A 29 A 55
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 61 and 87 (29 and 55 respectively in this structure).
Details
Redox score ?
84
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
5
% buried
26
Peptide accession
Q9UBF6
Residue number A
61
Residue number B
87
Peptide name
RING-box protein 2
Ligandability
Cysteine 61 of RING-box protein 2
Cysteine 87 of RING-box protein 2
2ecl A 48 A 70
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 80 and 102 (48 and 70 respectively in this structure).
Details
Redox score ?
84
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
7
% buried
8
Peptide accession
Q9UBF6
Residue number A
80
Residue number B
102
Peptide name
RING-box protein 2
Ligandability
Cysteine 80 of RING-box protein 2
Cysteine 102 of RING-box protein 2
6v9i R 53 R 88
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 53 and 88.
Details
Redox score ?
83
PDB code
6v9i
Structure name
cryo-em structure of cullin5 bound to ring-box protein 2 (cul5-rbx2)
Structure deposition date
2019-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WTZ1
Residue number A
53
Residue number B
88
Peptide name
RING-box protein 2
Ligandability
Cysteine 53 of RING-box protein 2
Cysteine 88 of RING-box protein 2
2ecl A 67 A 70
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 99 and 102 (67 and 70 respectively in this structure).
Details
Redox score ?
82
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
15
Peptide accession
Q9UBF6
Residue number A
99
Residue number B
102
Peptide name
RING-box protein 2
Ligandability
Cysteine 99 of RING-box protein 2
Cysteine 102 of RING-box protein 2
2ecl A 32 A 41
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 64 and 73 (32 and 41 respectively in this structure).
Details
Redox score ?
81
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
13
Peptide accession
Q9UBF6
Residue number A
64
Residue number B
73
Peptide name
RING-box protein 2
Ligandability
Cysteine 64 of RING-box protein 2
Cysteine 73 of RING-box protein 2
2ecl A 48 A 67
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 80 and 99 (48 and 67 respectively in this structure).
Details
Redox score ?
79
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
22
Peptide accession
Q9UBF6
Residue number A
80
Residue number B
99
Peptide name
RING-box protein 2
Ligandability
Cysteine 80 of RING-box protein 2
Cysteine 99 of RING-box protein 2
2ecl A 21 A 29
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 53 and 61 (21 and 29 respectively in this structure).
Details
Redox score ?
78
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
24
Peptide accession
Q9UBF6
Residue number A
53
Residue number B
61
Peptide name
RING-box protein 2
Ligandability
Cysteine 53 of RING-box protein 2
Cysteine 61 of RING-box protein 2
2ecl A 41 A 55
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 73 and 87 (41 and 55 respectively in this structure).
Details
Redox score ?
78
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
28
Peptide accession
Q9UBF6
Residue number A
73
Residue number B
87
Peptide name
RING-box protein 2
Ligandability
Cysteine 73 of RING-box protein 2
Cysteine 87 of RING-box protein 2
2ecl A 32 A 55
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 64 and 87 (32 and 55 respectively in this structure).
Details
Redox score ?
76
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
20
Peptide accession
Q9UBF6
Residue number A
64
Residue number B
87
Peptide name
RING-box protein 2
Ligandability
Cysteine 64 of RING-box protein 2
Cysteine 87 of RING-box protein 2
6v9i R 50 R 88
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 50 and 88.
Details
Redox score ?
75
PDB code
6v9i
Structure name
cryo-em structure of cullin5 bound to ring-box protein 2 (cul5-rbx2)
Structure deposition date
2019-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WTZ1
Residue number A
50
Residue number B
88
Peptide name
RING-box protein 2
Ligandability
Cysteine 50 of RING-box protein 2
Cysteine 88 of RING-box protein 2
2ecl A 55 A 56
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 87 and 88 (55 and 56 respectively in this structure).
Details
Redox score ?
72
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
41
Peptide accession
Q9UBF6
Residue number A
87
Residue number B
88
Peptide name
RING-box protein 2
Ligandability
Cysteine 87 of RING-box protein 2
Cysteine 88 of RING-box protein 2
6v9i R 61 R 88
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 61 and 88.
Details
Redox score ?
71
PDB code
6v9i
Structure name
cryo-em structure of cullin5 bound to ring-box protein 2 (cul5-rbx2)
Structure deposition date
2019-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WTZ1
Residue number A
61
Residue number B
88
Peptide name
RING-box protein 2
Ligandability
Cysteine 61 of RING-box protein 2
Cysteine 88 of RING-box protein 2
2ecl A 18 A 55
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 50 and 87 (18 and 55 respectively in this structure).
Details
Redox score ?
70
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
3
% buried
46
Peptide accession
Q9UBF6
Residue number A
50
Residue number B
87
Peptide name
RING-box protein 2
Ligandability
Cysteine 50 of RING-box protein 2
Cysteine 87 of RING-box protein 2
2ecl A 18 A 41
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 50 and 73 (18 and 41 respectively in this structure).
Details
Redox score ?
69
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
3
% buried
39
Peptide accession
Q9UBF6
Residue number A
50
Residue number B
73
Peptide name
RING-box protein 2
Ligandability
Cysteine 50 of RING-box protein 2
Cysteine 73 of RING-box protein 2
2ecl A 41 A 56
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 73 and 88 (41 and 56 respectively in this structure).
Details
Redox score ?
63
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
34
Peptide accession
Q9UBF6
Residue number A
73
Residue number B
88
Peptide name
RING-box protein 2
Ligandability
Cysteine 73 of RING-box protein 2
Cysteine 88 of RING-box protein 2
2ecl A 21 A 41
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 53 and 73 (21 and 41 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
28
Peptide accession
Q9UBF6
Residue number A
53
Residue number B
73
Peptide name
RING-box protein 2
Ligandability
Cysteine 53 of RING-box protein 2
Cysteine 73 of RING-box protein 2
6v9i R 50 R 61
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 50 and 61. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6v9i
Structure name
cryo-em structure of cullin5 bound to ring-box protein 2 (cul5-rbx2)
Structure deposition date
2019-12-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WTZ1
Residue number A
50
Residue number B
61
Peptide name
RING-box protein 2
Ligandability
Cysteine 50 of RING-box protein 2
Cysteine 61 of RING-box protein 2
2ecl A 21 A 55
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 53 and 87 (21 and 55 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
34
Peptide accession
Q9UBF6
Residue number A
53
Residue number B
87
Peptide name
RING-box protein 2
Ligandability
Cysteine 53 of RING-box protein 2
Cysteine 87 of RING-box protein 2
2ecl A 18 A 67
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 50 and 99 (18 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
3
% buried
43
Peptide accession
Q9UBF6
Residue number A
50
Residue number B
99
Peptide name
RING-box protein 2
Ligandability
Cysteine 50 of RING-box protein 2
Cysteine 99 of RING-box protein 2
2ecl A 32 A 56
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 64 and 88 (32 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
12
% buried
26
Peptide accession
Q9UBF6
Residue number A
64
Residue number B
88
Peptide name
RING-box protein 2
Ligandability
Cysteine 64 of RING-box protein 2
Cysteine 88 of RING-box protein 2
2ecl A 21 A 32
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 53 and 64 (21 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
18
Peptide accession
Q9UBF6
Residue number A
53
Residue number B
64
Peptide name
RING-box protein 2
Ligandability
Cysteine 53 of RING-box protein 2
Cysteine 64 of RING-box protein 2
2ecl A 15 A 70
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 47 and 102 (15 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
34
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UBF6
Residue number A
47
Residue number B
102
Peptide name
RING-box protein 2
Ligandability
Cysteine 47 of RING-box protein 2
Cysteine 102 of RING-box protein 2
2ecl A 15 A 67
A redox-regulated disulphide may form within RING-box protein 2 between cysteines 47 and 99 (15 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2ecl
Structure name
solution structure of the ring domain of the human ring-box protein 2
Structure deposition date
2007-02-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
15
Peptide accession
Q9UBF6
Residue number A
47
Residue number B
99
Peptide name
RING-box protein 2
Ligandability
Cysteine 47 of RING-box protein 2
Cysteine 99 of RING-box protein 2
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