ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Phosphatidylinositol 4-kinase beta

Intramolecular
Cysteine 202 and cysteine 212
Cysteine 661 and cysteine 664
Cysteine 657 and cysteine 661
Cysteine 657 and cysteine 664
A redox-regulated disulphide may form within Phosphatidylinositol 4-kinase beta between cysteines 202 and 212.

Details

Redox score ?
75
PDB code
5fbl
Structure name
pi4kb in complex with rab11 and the mi356 inhibitor
Structure deposition date
2015-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
81
Peptide accession
Q9UBF8
Residue number A
202
Residue number B
212
Peptide name
Phosphatidylinositol 4-kinase beta

Ligandability

Cysteine 202 of Phosphatidylinositol 4-kinase beta

Cysteine 212 of Phosphatidylinositol 4-kinase beta

A redox-regulated disulphide may form within Phosphatidylinositol 4-kinase beta between cysteines 661 and 664. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5fbr
Structure name
pi4kb in complex with rab11 and the mi359 inhibitor
Structure deposition date
2015-12-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
100
Peptide accession
Q9UBF8
Residue number A
661
Residue number B
664
Peptide name
Phosphatidylinositol 4-kinase beta

Ligandability

Cysteine 661 of Phosphatidylinositol 4-kinase beta

Cysteine 664 of Phosphatidylinositol 4-kinase beta

A redox-regulated disulphide may form within Phosphatidylinositol 4-kinase beta between cysteines 657 and 661. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5fbv
Structure name
pi4kb in complex with rab11 and the mi364 inhibitor
Structure deposition date
2015-12-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UBF8
Residue number A
657
Residue number B
661
Peptide name
Phosphatidylinositol 4-kinase beta

Ligandability

Cysteine 657 of Phosphatidylinositol 4-kinase beta

Cysteine 661 of Phosphatidylinositol 4-kinase beta

A redox-regulated disulphide may form within Phosphatidylinositol 4-kinase beta between cysteines 657 and 664. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
5fbv
Structure name
pi4kb in complex with rab11 and the mi364 inhibitor
Structure deposition date
2015-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UBF8
Residue number A
657
Residue number B
664
Peptide name
Phosphatidylinositol 4-kinase beta

Ligandability

Cysteine 657 of Phosphatidylinositol 4-kinase beta

Cysteine 664 of Phosphatidylinositol 4-kinase beta

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