ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

C-type mannose receptor 2

Intramolecular
Cysteine 54 and cysteine 68
Cysteine 123 and cysteine 168
Cysteine 382 and cysteine 393
Cysteine 235 and cysteine 248
Cysteine 93 and cysteine 112
Cysteine 201 and cysteine 228
Cysteine 335 and cysteine 351
Cysteine 410 and cysteine 504
Cysteine 187 and cysteine 213
Cysteine 266 and cysteine 359
More...
Cysteine 481 and cysteine 496
Cysteine 187 and cysteine 228
Cysteine 187 and cysteine 201
Cysteine 213 and cysteine 228
Cysteine 201 and cysteine 213
A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 54 and 68.

Details

Redox score ?
86
PDB code
5ao5
Structure name
endo180 d1-4, monoclinic form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
54
Residue number B
68
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 54 of C-type mannose receptor 2

Cysteine 68 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 123 and 168.

Details

Redox score ?
86
PDB code
5ao6
Structure name
endo180 d1-4, trigonal form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
123
Residue number B
168
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 123 of C-type mannose receptor 2

Cysteine 168 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 382 and 393.

Details

Redox score ?
85
PDB code
5ew6
Structure name
structure of ligand binding region of uparap at ph 7
Structure deposition date
2015-11-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
382
Residue number B
393
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 382 of C-type mannose receptor 2

Cysteine 393 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 235 and 248.

Details

Redox score ?
84
PDB code
5e4k
Structure name
structure of ligand binding region of uparap at ph 7
Structure deposition date
2015-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
235
Residue number B
248
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 235 of C-type mannose receptor 2

Cysteine 248 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 93 and 112.

Details

Redox score ?
83
PDB code
5ao6
Structure name
endo180 d1-4, trigonal form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
93
Residue number B
112
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 93 of C-type mannose receptor 2

Cysteine 112 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 201 and 228.

Details

Redox score ?
83
PDB code
5ao6
Structure name
endo180 d1-4, trigonal form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
201
Residue number B
228
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 201 of C-type mannose receptor 2

Cysteine 228 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 335 and 351.

Details

Redox score ?
82
PDB code
5e4l
Structure name
structure of ligand binding region of uparap at ph 5
Structure deposition date
2015-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
335
Residue number B
351
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 335 of C-type mannose receptor 2

Cysteine 351 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 410 and 504.

Details

Redox score ?
81
PDB code
5ao5
Structure name
endo180 d1-4, monoclinic form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
410
Residue number B
504
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 410 of C-type mannose receptor 2

Cysteine 504 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 187 and 213.

Details

Redox score ?
79
PDB code
5ao6
Structure name
endo180 d1-4, trigonal form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
187
Residue number B
213
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 187 of C-type mannose receptor 2

Cysteine 213 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 266 and 359.

Details

Redox score ?
79
PDB code
5ao6
Structure name
endo180 d1-4, trigonal form
Structure deposition date
2015-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
266
Residue number B
359
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 266 of C-type mannose receptor 2

Cysteine 359 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 481 and 496.

Details

Redox score ?
77
PDB code
5e4l
Structure name
structure of ligand binding region of uparap at ph 5
Structure deposition date
2015-10-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
13
Peptide accession
Q9UBG0
Residue number A
481
Residue number B
496
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 481 of C-type mannose receptor 2

Cysteine 496 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 187 and 228.

Details

Redox score ?
70
PDB code
5e4l
Structure name
structure of ligand binding region of uparap at ph 5
Structure deposition date
2015-10-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
187
Residue number B
228
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 187 of C-type mannose receptor 2

Cysteine 228 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 187 and 201.

Details

Redox score ?
69
PDB code
5ao5
Structure name
endo180 d1-4, monoclinic form
Structure deposition date
2015-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
187
Residue number B
201
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 187 of C-type mannose receptor 2

Cysteine 201 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 213 and 228.

Details

Redox score ?
68
PDB code
5ao5
Structure name
endo180 d1-4, monoclinic form
Structure deposition date
2015-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
213
Residue number B
228
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 213 of C-type mannose receptor 2

Cysteine 228 of C-type mannose receptor 2

A redox-regulated disulphide may form within C-type mannose receptor 2 between cysteines 201 and 213.

Details

Redox score ?
62
PDB code
5ew6
Structure name
structure of ligand binding region of uparap at ph 7
Structure deposition date
2015-11-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBG0
Residue number A
201
Residue number B
213
Peptide name
C-type mannose receptor 2

Ligandability

Cysteine 201 of C-type mannose receptor 2

Cysteine 213 of C-type mannose receptor 2

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