ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Methionine synthase reductase

Intramolecular
Cysteine 317 and cysteine 489
Cysteine 364 and cysteine 373
A redox-regulated disulphide may form within Methionine synthase reductase between cysteines 317 and 489.

Details

Redox score ?
71
PDB code
2qtz
Structure name
crystal structure of the nadp+-bound fad-containing fnr-like module of human methionine synthase reductase
Structure deposition date
2007-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
94
Peptide accession
Q9UBK8
Residue number A
317
Residue number B
489
Peptide name
Methionine synthase reductase

Ligandability

Cysteine 317 of Methionine synthase reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of Methionine synthase reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine synthase reductase between cysteines 364 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2qtz
Structure name
crystal structure of the nadp+-bound fad-containing fnr-like module of human methionine synthase reductase
Structure deposition date
2007-08-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
26
Peptide accession
Q9UBK8
Residue number A
364
Residue number B
373
Peptide name
Methionine synthase reductase

Ligandability

Cysteine 364 of Methionine synthase reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Methionine synthase reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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