a tool for identifying drug-targetable redox-active disulphides

Short transient receptor potential channel 4

Intramolecular

Cysteine 549 and cysteine 554

A redox-regulated disulphide may form within Short transient receptor potential channel 4 between cysteines 549 and 554.

Details

Redox score ?

86

PDB code

Structure name

structure of the mouse trpc4 ion channel

Structure deposition date

2019-05-03

Thiol separation (Å)

2

Half-sphere exposure sum ?

48

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

549

Residue number B

554

Peptide name

Short transient receptor potential channel 4

Ligandability

Cysteine 549 of Short transient receptor potential channel 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 554 of Short transient receptor potential channel 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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