Cathepsin Z
Intramolecular
Cysteine 173 and cysteine 179 L
Cysteine 89 and cysteine 132
Cysteine 33 and cysteine 92 L
Cysteine 126 and cysteine 164
Cysteine 154 and cysteine 170
Cysteine 214 and cysteine 296
Cysteine 33 and cysteine 89
Cysteine 89 and cysteine 92 L
Cysteine 92 and cysteine 132 L
1ef7 A 112 A 118
A redox-regulated disulphide may form within Cathepsin Z between cysteines 173 and 179 (112 and 118 respectively in this structure).
Details
Redox score ?
88
PDB code
1ef7
Structure name
crystal structure of human cathepsin x
Structure deposition date
2000-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
32
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBR2
Residue number A
173
Residue number B
179
Peptide name
Cathepsin Z
Ligandability
Cysteine 173 of Cathepsin Z
Cysteine 179 of Cathepsin Z
1ef7 A 28 A 71
A redox-regulated disulphide may form within Cathepsin Z between cysteines 89 and 132 (28 and 71 respectively in this structure).
Details
Redox score ?
86
PDB code
1ef7
Structure name
crystal structure of human cathepsin x
Structure deposition date
2000-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBR2
Residue number A
89
Residue number B
132
Peptide name
Cathepsin Z
Ligandability
Cysteine 89 of Cathepsin Z
Cysteine 132 of Cathepsin Z
1deu A 10 A 31
A redox-regulated disulphide may form within Cathepsin Z between cysteines 33 and 92 (10 and 31 respectively in this structure).
Details
Redox score ?
86
PDB code
1deu
Structure name
crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine
Structure deposition date
1999-11-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
4
% buried
100
Peptide accession
Q9UBR2
Residue number A
33
Residue number B
92
Peptide name
Cathepsin Z
Ligandability
Cysteine 33 of Cathepsin Z
Cysteine 92 of Cathepsin Z
1deu B 65 B 103
A redox-regulated disulphide may form within Cathepsin Z between cysteines 126 and 164 (65 and 103 respectively in this structure).
Details
Redox score ?
84
PDB code
1deu
Structure name
crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine
Structure deposition date
1999-11-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBR2
Residue number A
126
Residue number B
164
Peptide name
Cathepsin Z
Ligandability
Cysteine 126 of Cathepsin Z
Cysteine 164 of Cathepsin Z
1deu B 93 B 109
A redox-regulated disulphide may form within Cathepsin Z between cysteines 154 and 170 (93 and 109 respectively in this structure).
Details
Redox score ?
83
PDB code
1deu
Structure name
crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine
Structure deposition date
1999-11-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBR2
Residue number A
154
Residue number B
170
Peptide name
Cathepsin Z
Ligandability
Cysteine 154 of Cathepsin Z
Cysteine 170 of Cathepsin Z
1deu B 153 B 235
A redox-regulated disulphide may form within Cathepsin Z between cysteines 214 and 296 (153 and 235 respectively in this structure).
Details
Redox score ?
79
PDB code
1deu
Structure name
crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine
Structure deposition date
1999-11-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBR2
Residue number A
214
Residue number B
296
Peptide name
Cathepsin Z
Ligandability
Cysteine 214 of Cathepsin Z
Cysteine 296 of Cathepsin Z
1deu A 10 A 28
A redox-regulated disulphide may form within Cathepsin Z between cysteines 33 and 89 (10 and 28 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
1deu
Structure name
crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine
Structure deposition date
1999-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
4
% buried
nan
Peptide accession
Q9UBR2
Residue number A
33
Residue number B
89
Peptide name
Cathepsin Z
Ligandability
Cysteine 33 of Cathepsin Z
Cysteine 89 of Cathepsin Z
1ef7 A 28 A 31
A redox-regulated disulphide may form within Cathepsin Z between cysteines 89 and 92 (28 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
1ef7
Structure name
crystal structure of human cathepsin x
Structure deposition date
2000-02-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UBR2
Residue number A
89
Residue number B
92
Peptide name
Cathepsin Z
Ligandability
Cysteine 89 of Cathepsin Z
Cysteine 92 of Cathepsin Z
1ef7 B 31 B 71
A redox-regulated disulphide may form within Cathepsin Z between cysteines 92 and 132 (31 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1ef7
Structure name
crystal structure of human cathepsin x
Structure deposition date
2000-02-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UBR2
Residue number A
92
Residue number B
132
Peptide name
Cathepsin Z
Ligandability
Cysteine 92 of Cathepsin Z
Cysteine 132 of Cathepsin Z
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