ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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LIM/homeobox protein Lhx3

Intramolecular
Cysteine 34 and cysteine 37
Cysteine 93 and cysteine 96
Cysteine 61 and cysteine 64
Cysteine 121 and cysteine 124
Cysteine 37 and cysteine 58
Cysteine 121 and cysteine 144
Cysteine 93 and cysteine 118
Cysteine 61 and cysteine 81
Cysteine 96 and cysteine 118
Cysteine 34 and cysteine 58
More...
Cysteine 124 and cysteine 144
Cysteine 64 and cysteine 81
Cysteine 61 and cysteine 72
Cysteine 72 and cysteine 81
A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 34 and 37 (63 and 66 respectively in this structure).

Details

Redox score ?
83
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
8
Peptide accession
P50481
Residue number A
34
Residue number B
37
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 34 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 93 and 96 (122 and 125 respectively in this structure).

Details

Redox score ?
82
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
16
Peptide accession
P50481
Residue number A
93
Residue number B
96
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 93 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 61 and 64 (90 and 93 respectively in this structure).

Details

Redox score ?
81
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
14
Peptide accession
P50481
Residue number A
61
Residue number B
64
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 61 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 121 and 124 (150 and 153 respectively in this structure).

Details

Redox score ?
81
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
10
Peptide accession
P50481
Residue number A
121
Residue number B
124
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 121 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 37 and 58 (66 and 87 respectively in this structure).

Details

Redox score ?
81
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
6
Peptide accession
P50481
Residue number A
37
Residue number B
58
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 37 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 121 and 144 (150 and 173 respectively in this structure).

Details

Redox score ?
80
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
15
Peptide accession
P50481
Residue number A
121
Residue number B
144
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 121 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 93 and 118 (122 and 147 respectively in this structure).

Details

Redox score ?
80
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
24
Peptide accession
P50481
Residue number A
93
Residue number B
118
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 93 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 61 and 81 (90 and 110 respectively in this structure).

Details

Redox score ?
78
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
28
Peptide accession
P50481
Residue number A
61
Residue number B
81
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 61 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 96 and 118 (125 and 147 respectively in this structure).

Details

Redox score ?
76
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
11
Peptide accession
P50481
Residue number A
96
Residue number B
118
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 96 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 34 and 58 (63 and 87 respectively in this structure).

Details

Redox score ?
76
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
14
Peptide accession
P50481
Residue number A
34
Residue number B
58
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 34 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 124 and 144 (153 and 173 respectively in this structure).

Details

Redox score ?
74
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
6
Peptide accession
P50481
Residue number A
124
Residue number B
144
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 124 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 64 and 81 (93 and 110 respectively in this structure).

Details

Redox score ?
74
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
11
% buried
18
Peptide accession
P50481
Residue number A
64
Residue number B
81
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 64 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 61 and 72 (90 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
42
Peptide accession
P50481
Residue number A
61
Residue number B
72
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 61 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM/homeobox protein Lhx3 between cysteines 72 and 81 (101 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2jtn
Structure name
nmr solution structure of a ldb1-lid:lhx3-lim complex
Structure deposition date
2007-08-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
46
Peptide accession
P50481
Residue number A
72
Residue number B
81
Peptide name
LIM/homeobox protein Lhx3

Ligandability

Cysteine 72 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of LIM/homeobox protein Lhx3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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