ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Dickkopf-related protein 4

Intramolecular
Cysteine 47 and cysteine 63
Cysteine 73 and cysteine 85
Cysteine 41 and cysteine 53
Cysteine 79 and cysteine 90
Cysteine 66 and cysteine 80
Cysteine 73 and cysteine 79
Cysteine 53 and cysteine 63
Cysteine 47 and cysteine 53
Cysteine 41 and cysteine 63
Cysteine 73 and cysteine 90
More...
Cysteine 79 and cysteine 85
Cysteine 41 and cysteine 47
Cysteine 85 and cysteine 90
Cysteine 66 and cysteine 90
Cysteine 80 and cysteine 90
Cysteine 79 and cysteine 80
Cysteine 66 and cysteine 79
Cysteine 47 and cysteine 66
Cysteine 63 and cysteine 80
Cysteine 63 and cysteine 66
Cysteine 73 and cysteine 80
Cysteine 47 and cysteine 80
Cysteine 80 and cysteine 85
Cysteine 66 and cysteine 85
A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 47 and 63.

Details

Redox score ?
89
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
47
Residue number B
63
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 47 of Dickkopf-related protein 4

Cysteine 63 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 73 and 85.

Details

Redox score ?
87
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
73
Residue number B
85
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 73 of Dickkopf-related protein 4

Cysteine 85 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 41 and 53.

Details

Redox score ?
87
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
41
Residue number B
53
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 41 of Dickkopf-related protein 4

Cysteine 53 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 79 and 90.

Details

Redox score ?
85
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
79
Residue number B
90
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 79 of Dickkopf-related protein 4

Cysteine 90 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 66 and 80.

Details

Redox score ?
82
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
66
Residue number B
80
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 66 of Dickkopf-related protein 4

Cysteine 80 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 73 and 79.

Details

Redox score ?
77
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
73
Residue number B
79
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 73 of Dickkopf-related protein 4

Cysteine 79 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 53 and 63.

Details

Redox score ?
76
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
53
Residue number B
63
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 53 of Dickkopf-related protein 4

Cysteine 63 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 47 and 53.

Details

Redox score ?
71
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
47
Residue number B
53
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 47 of Dickkopf-related protein 4

Cysteine 53 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 41 and 63.

Details

Redox score ?
71
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
41
Residue number B
63
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 41 of Dickkopf-related protein 4

Cysteine 63 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 73 and 90.

Details

Redox score ?
71
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
73
Residue number B
90
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 73 of Dickkopf-related protein 4

Cysteine 90 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 79 and 85.

Details

Redox score ?
65
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
79
Residue number B
85
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 79 of Dickkopf-related protein 4

Cysteine 85 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 41 and 47.

Details

Redox score ?
64
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
41
Residue number B
47
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 41 of Dickkopf-related protein 4

Cysteine 47 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 85 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
85
Residue number B
90
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 85 of Dickkopf-related protein 4

Cysteine 90 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 66 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
66
Residue number B
90
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 66 of Dickkopf-related protein 4

Cysteine 90 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 80 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
80
Residue number B
90
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 80 of Dickkopf-related protein 4

Cysteine 90 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 79 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
79
Residue number B
80
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 79 of Dickkopf-related protein 4

Cysteine 80 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 66 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
66
Residue number B
79
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 66 of Dickkopf-related protein 4

Cysteine 79 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 47 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
47
Residue number B
66
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 47 of Dickkopf-related protein 4

Cysteine 66 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 63 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
63
Residue number B
80
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 63 of Dickkopf-related protein 4

Cysteine 80 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 63 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
63
Residue number B
66
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 63 of Dickkopf-related protein 4

Cysteine 66 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 73 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
73
Residue number B
80
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 73 of Dickkopf-related protein 4

Cysteine 80 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 47 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
47
Residue number B
80
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 47 of Dickkopf-related protein 4

Cysteine 80 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 80 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
80
Residue number B
85
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 80 of Dickkopf-related protein 4

Cysteine 85 of Dickkopf-related protein 4

A redox-regulated disulphide may form within Dickkopf-related protein 4 between cysteines 66 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5o57
Structure name
solution structure of the n-terminal region of dkk4
Structure deposition date
2017-06-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBT3
Residue number A
66
Residue number B
85
Peptide name
Dickkopf-related protein 4

Ligandability

Cysteine 66 of Dickkopf-related protein 4

Cysteine 85 of Dickkopf-related protein 4

If this tool was useful for finding a disulphide, please cite: