a tool for identifying drug-targetable redox-active disulphides

DNA polymerase kappa

Intramolecular

Cysteine 435 and cysteine 439

A redox-regulated disulphide may form within DNA polymerase kappa between cysteines 435 and 439.

Details

Redox score ?

78

PDB code

Structure name

human dna polymerase kappa extending opposite a cis-syn thymine dimer

Structure deposition date

2010-12-14

Thiol separation (Å)

3

Half-sphere exposure sum ?

78

Minimum pK_a ?

8

% buried

66

Peptide accession

Residue number A

435

Residue number B

439

Peptide name

DNA polymerase kappa

Ligandability

Cysteine 435 of DNA polymerase kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 439 of DNA polymerase kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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