ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein DBF4 homolog A

Intramolecular
Cysteine 296 and cysteine 299
Cysteine 296 and cysteine 298
Cysteine 298 and cysteine 299
A redox-regulated disulphide may form within Protein DBF4 homolog A between cysteines 296 and 299.

Details

Redox score ?
92
PDB code
4f9b
Structure name
human cdc7 kinase in complex with dbf4 and pha767491
Structure deposition date
2012-05-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
2
% buried
38
Peptide accession
Q9UBU7
Residue number A
296
Residue number B
299
Peptide name
Protein DBF4 homolog A

Ligandability

Cysteine 296 of Protein DBF4 homolog A

Cysteine 299 of Protein DBF4 homolog A

A redox-regulated disulphide may form within Protein DBF4 homolog A between cysteines 296 and 298.

Details

Redox score ?
74
PDB code
4f9a
Structure name
human cdc7 kinase in complex with dbf4 and nucleotide
Structure deposition date
2012-05-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
54
Peptide accession
Q9UBU7
Residue number A
296
Residue number B
298
Peptide name
Protein DBF4 homolog A

Ligandability

Cysteine 296 of Protein DBF4 homolog A

Cysteine 298 of Protein DBF4 homolog A

A redox-regulated disulphide may form within Protein DBF4 homolog A between cysteines 298 and 299.

Details

Redox score ?
61
PDB code
4f9c
Structure name
human cdc7 kinase in complex with dbf4 and xl413
Structure deposition date
2012-05-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBU7
Residue number A
298
Residue number B
299
Peptide name
Protein DBF4 homolog A

Ligandability

Cysteine 298 of Protein DBF4 homolog A

Cysteine 299 of Protein DBF4 homolog A

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