ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nuclear RNA export factor 1

Intermolecular
Cysteine 492 and cysteine 132 of NTF2-related export protein 1
Intramolecular
Cysteine 415 and cysteine 416
A redox-regulated disulphide may form between cysteine 492 of Nuclear RNA export factor 1 and cysteine 132 of NTF2-related export protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4wyk
Structure name
structure of the lrr and ntf2-like domains of nxf1 complexed with nxt1
Structure deposition date
2014-11-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide A name
Nuclear RNA export factor 1
Peptide B name
NTF2-related export protein 1
Peptide A accession
Q9UBU9
Peptide B accession
Q9UKK6
Peptide A residue number
492
Peptide B residue number
132

Ligandability

Cysteine 492 of Nuclear RNA export factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of NTF2-related export protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear RNA export factor 1 between cysteines 415 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
1jkg
Structure name
structural basis for the recognition of a nucleoporin fg- repeat by the ntf2-like domain of tap-p15 mrna nuclear export factor
Structure deposition date
2001-07-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UBU9
Residue number A
415
Residue number B
416
Peptide name
Nuclear RNA export factor 1

Ligandability

Cysteine 415 of Nuclear RNA export factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of Nuclear RNA export factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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