ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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COP9 signalosome complex subunit 7a

Intermolecular
Cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 181
Intramolecular
Cysteine 178 and cysteine 181
A redox-regulated disulphide may form between cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 181 of COP9 signalosome complex subunit 7a. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4d10
Structure name
crystal structure of the cop9 signalosome
Structure deposition date
2014-04-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
13
% buried
98
Peptide A name
COP9 signalosome complex subunit 4
Peptide B name
COP9 signalosome complex subunit 7a
Peptide A accession
Q9BT78
Peptide B accession
Q9UBW8
Peptide A residue number
378
Peptide B residue number
181

Ligandability

Cysteine 378 of COP9 signalosome complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within COP9 signalosome complex subunit 7a between cysteines 178 and 181. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4d18
Structure name
crystal structure of the cop9 signalosome
Structure deposition date
2014-05-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
82
Peptide accession
Q9UBW8
Residue number A
178
Residue number B
181
Peptide name
COP9 signalosome complex subunit 7a

Ligandability

Cysteine 178 of COP9 signalosome complex subunit 7a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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