ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cathepsin F

Intramolecular
Cysteine 292 and cysteine 333
Cysteine 326 and cysteine 366
Cysteine 424 and cysteine 472
Cysteine 292 and cysteine 295
A redox-regulated disulphide may form within Cathepsin F between cysteines 292 and 333 (22 and 63 respectively in this structure).

Details

Redox score ?
86
PDB code
1m6d
Structure name
crystal structure of human cathepsin f
Structure deposition date
2002-07-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBX1
Residue number A
292
Residue number B
333
Peptide name
Cathepsin F

Ligandability

Cysteine 292 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cathepsin F between cysteines 326 and 366 (56 and 95 respectively in this structure).

Details

Redox score ?
85
PDB code
1m6d
Structure name
crystal structure of human cathepsin f
Structure deposition date
2002-07-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBX1
Residue number A
326
Residue number B
366
Peptide name
Cathepsin F

Ligandability

Cysteine 326 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 366 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cathepsin F between cysteines 424 and 472 (153 and 200 respectively in this structure).

Details

Redox score ?
84
PDB code
1m6d
Structure name
crystal structure of human cathepsin f
Structure deposition date
2002-07-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UBX1
Residue number A
424
Residue number B
472
Peptide name
Cathepsin F

Ligandability

Cysteine 424 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cathepsin F between cysteines 292 and 295 (22 and 25 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1m6d
Structure name
crystal structure of human cathepsin f
Structure deposition date
2002-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
13
% buried
nan
Peptide accession
Q9UBX1
Residue number A
292
Residue number B
295
Peptide name
Cathepsin F

Ligandability

Cysteine 292 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Cathepsin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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