ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Intramolecular
Cysteine 77 and cysteine 91 L
Cysteine 148 and cysteine 190
Cysteine 248 and cysteine 290
Cysteine 596 and cysteine 628
Cysteine 493 and cysteine 539
Cysteine 230 and cysteine 248
Cysteine 209 and cysteine 230
Cysteine 147 and cysteine 148
Cysteine 464 and cysteine 493
Cysteine 447 and cysteine 449 L
Cysteine 147 and cysteine 190
A redox-regulated disulphide may form within Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 77 and 91.

Details

Redox score ?
81
PDB code
2g7r
Structure name
x-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2006-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UDY8
Residue number A
77
Residue number B
91
Peptide name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 77 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 148 and 190.

Details

Redox score ?
74
PDB code
3k0w
Structure name
crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2009-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
58
Peptide accession
Q9UDY8-2
Residue number A
148
Residue number B
190
Peptide name
Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 148 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 248 and 290.

Details

Redox score ?
72
PDB code
3k0w
Structure name
crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2009-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
74
Peptide accession
Q9UDY8-2
Residue number A
248
Residue number B
290
Peptide name
Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 248 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 596 and 628.

Details

Redox score ?
61
PDB code
7paw
Structure name
malt1 in complex with compound 1
Structure deposition date
2021-07-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
11
Peptide accession
Q9UDY8
Residue number A
596
Residue number B
628
Peptide name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 596 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 628 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 493 and 539. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4i1r
Structure name
human malt1 (caspase-ig3) in complex with thioridazine
Structure deposition date
2012-11-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
30
Peptide accession
Q9UDY8
Residue number A
493
Residue number B
539
Peptide name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 493 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 539 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 230 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3bfo
Structure name
crystal structure of ig-like c2-type 2 domain of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2007-11-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
26
Peptide accession
Q9UDY8
Residue number A
230
Residue number B
248
Peptide name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 230 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 209 and 230. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3k0w
Structure name
crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2009-09-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
64
Peptide accession
Q9UDY8-2
Residue number A
209
Residue number B
230
Peptide name
Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 209 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 147 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3k0w
Structure name
crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2009-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
44
Peptide accession
Q9UDY8-2
Residue number A
147
Residue number B
148
Peptide name
Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 147 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 464 and 493. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6h4a
Structure name
human malt1(329-728) in complex with mlt-748
Structure deposition date
2018-07-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
65
Peptide accession
Q9UDY8
Residue number A
464
Residue number B
493
Peptide name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 464 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 493 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog between cysteines 447 and 449. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3v4l
Structure name
mouse malt1(caspase-ig3 domains) in complex with a irreversible peptidic inhibitor
Structure deposition date
2011-12-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
81
Peptide accession
Q2TBA3
Residue number A
447
Residue number B
449
Peptide name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Ligandability

Cysteine 447 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 449 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 between cysteines 147 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3k0w
Structure name
crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
Structure deposition date
2009-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
52
Peptide accession
Q9UDY8-2
Residue number A
147
Residue number B
190
Peptide name
Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Ligandability

Cysteine 147 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Isoform 2 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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