ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Macrophage receptor MARCO

Intramolecular
Cysteine 487 and cysteine 497
Cysteine 459 and cysteine 517
Cysteine 446 and cysteine 507
A redox-regulated disulphide may form within Macrophage receptor MARCO between cysteines 487 and 497.

Details

Redox score ?
89
PDB code
2oya
Structure name
crystal structure analysis of the dimeric form of the srcr domain of mouse marco
Structure deposition date
2007-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60754
Residue number A
487
Residue number B
497
Peptide name
Macrophage receptor MARCO

Ligandability

Cysteine 487 of Macrophage receptor MARCO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 497 of Macrophage receptor MARCO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage receptor MARCO between cysteines 459 and 517.

Details

Redox score ?
85
PDB code
2oy3
Structure name
crystal structure analysis of the monomeric srcr domain of mouse marco
Structure deposition date
2007-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60754
Residue number A
459
Residue number B
517
Peptide name
Macrophage receptor MARCO

Ligandability

Cysteine 459 of Macrophage receptor MARCO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 517 of Macrophage receptor MARCO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage receptor MARCO between cysteines 446 and 507.

Details

Redox score ?
82
PDB code
2oy3
Structure name
crystal structure analysis of the monomeric srcr domain of mouse marco
Structure deposition date
2007-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60754
Residue number A
446
Residue number B
507
Peptide name
Macrophage receptor MARCO

Ligandability

Cysteine 446 of Macrophage receptor MARCO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 507 of Macrophage receptor MARCO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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