ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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STE20/SPS1-related proline-alanine-rich protein kinase

Intermolecular
Cysteine 525 and cysteine 525
Intramolecular
Cysteine 329 and cysteine 346 L
A redox-regulated disulphide may form between two units of STE20/SPS1-related proline-alanine-rich protein kinase at cysteines 525 and 525.

Details

Redox score ?
62
PDB code
7o86
Structure name
1
Structure deposition date
2021-04-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
48
Peptide A name
STE20/SPS1-related proline-alanine-rich protein kinase
Peptide B name
STE20/SPS1-related proline-alanine-rich protein kinase
Peptide A accession
Q9UEW8
Peptide B accession
Q9UEW8
Peptide A residue number
525
Peptide B residue number
525

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within STE20/SPS1-related proline-alanine-rich protein kinase between cysteines 329 and 346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5d9h
Structure name
crystal structure of spak (stk39) dimer in the basal activity state
Structure deposition date
2015-08-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
64
Peptide accession
Q9Z1W9
Residue number A
329
Residue number B
346
Peptide name
STE20/SPS1-related proline-alanine-rich protein kinase

Ligandability

Cysteine 329 of STE20/SPS1-related proline-alanine-rich protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 346 of STE20/SPS1-related proline-alanine-rich protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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