a tool for identifying drug-targetable redox-active disulphides

Pleckstrin homology domain-containing family B member 1

Intramolecular

Cysteine 81 and cysteine 109

A redox-regulated disulphide may form within Pleckstrin homology domain-containing family B member 1 between cysteines 81 and 109 (67 and 95 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

solution structure of the ph domain of pleckstrin homology domain- containing protein family b member 1 from mouse

Structure deposition date

2005-12-13

Thiol separation (Å)

9

Half-sphere exposure sum ?

73

Minimum pK_a ?

10

% buried

42

Peptide accession

Residue number A

81

Residue number B

109

Peptide name

Pleckstrin homology domain-containing family B member 1

Ligandability

Cysteine 81 of Pleckstrin homology domain-containing family B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Pleckstrin homology domain-containing family B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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