ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ubiquitin thioesterase ZRANB1

Intramolecular
Cysteine 13 and cysteine 24
Cysteine 24 and cysteine 27
Cysteine 10 and cysteine 27
Cysteine 10 and cysteine 24
Cysteine 13 and cysteine 27
Cysteine 10 and cysteine 13
A redox-regulated disulphide may form within Ubiquitin thioesterase ZRANB1 between cysteines 13 and 24.

Details

Redox score ?
89
PDB code
4s1z
Structure name
crystal structure of trabid nzf1 in complex with k29 linked di- ubiquitin
Structure deposition date
2015-01-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
5
% buried
1
Peptide accession
A6QP16
Residue number A
13
Residue number B
24
Peptide name
Ubiquitin thioesterase ZRANB1

Ligandability

Cysteine 13 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin thioesterase ZRANB1 between cysteines 24 and 27.

Details

Redox score ?
87
PDB code
4s1z
Structure name
crystal structure of trabid nzf1 in complex with k29 linked di- ubiquitin
Structure deposition date
2015-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
5
% buried
1
Peptide accession
A6QP16
Residue number A
24
Residue number B
27
Peptide name
Ubiquitin thioesterase ZRANB1

Ligandability

Cysteine 24 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin thioesterase ZRANB1 between cysteines 10 and 27.

Details

Redox score ?
86
PDB code
5af6
Structure name
structure of lys33-linked diub bound to trabid nzf1
Structure deposition date
2015-01-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
13
Peptide accession
Q9UGI0
Residue number A
10
Residue number B
27
Peptide name
Ubiquitin thioesterase ZRANB1

Ligandability

Cysteine 10 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin thioesterase ZRANB1 between cysteines 10 and 24.

Details

Redox score ?
81
PDB code
4s1z
Structure name
crystal structure of trabid nzf1 in complex with k29 linked di- ubiquitin
Structure deposition date
2015-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
29
Peptide accession
A6QP16
Residue number A
10
Residue number B
24
Peptide name
Ubiquitin thioesterase ZRANB1

Ligandability

Cysteine 10 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin thioesterase ZRANB1 between cysteines 13 and 27.

Details

Redox score ?
80
PDB code
4s1z
Structure name
crystal structure of trabid nzf1 in complex with k29 linked di- ubiquitin
Structure deposition date
2015-01-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
30
Peptide accession
A6QP16
Residue number A
13
Residue number B
27
Peptide name
Ubiquitin thioesterase ZRANB1

Ligandability

Cysteine 13 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin thioesterase ZRANB1 between cysteines 10 and 13.

Details

Redox score ?
78
PDB code
5af6
Structure name
structure of lys33-linked diub bound to trabid nzf1
Structure deposition date
2015-01-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
43
Peptide accession
Q9UGI0
Residue number A
10
Residue number B
13
Peptide name
Ubiquitin thioesterase ZRANB1

Ligandability

Cysteine 10 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 13 of Ubiquitin thioesterase ZRANB1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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