ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Signal-transducing adaptor protein 2

Intramolecular
Cysteine 153 and cysteine 172
A redox-regulated disulphide may form within Signal-transducing adaptor protein 2 between cysteines 153 and 172 (24 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2el8
Structure name
solution structure of the human stap2 sh2 domain
Structure deposition date
2007-03-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
22
Peptide accession
Q9UGK3
Residue number A
153
Residue number B
172
Peptide name
Signal-transducing adaptor protein 2

Ligandability

Cysteine 153 of Signal-transducing adaptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Signal-transducing adaptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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