ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Deleted in malignant brain tumors 1 protein

Intramolecular
Cysteine 171 and cysteine 181
Cysteine 372 and cysteine 145
Cysteine 140 and cysteine 1739
Cysteine 140 and cysteine 201
Cysteine 111 and cysteine 145
Cysteine 127 and cysteine 191
Cysteine 127 and cysteine 583
Cysteine 145 and cysteine 201
Cysteine 145 and cysteine 1739
Cysteine 372 and cysteine 1739
More...
Cysteine 111 and cysteine 1739
Cysteine 372 and cysteine 201
Cysteine 140 and cysteine 145
Cysteine 372 and cysteine 140
Cysteine 111 and cysteine 140
A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 171 and 181 (1062 and 1072 respectively in this structure).

Details

Redox score ?
88
PDB code
6sa5
Structure name
salsa / dmbt1 / gp340 srcr domain 8
Structure deposition date
2019-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
171
Residue number B
181
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 171 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 372 and 145 (1002 and 1036 respectively in this structure).

Details

Redox score ?
85
PDB code
6san
Structure name
salsa / dmbt1 / gp340 srcr domain 8 soaked in calcium and magnesium
Structure deposition date
2019-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
372
Residue number B
145
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 372 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 140 and 1739 (140 and 201 respectively in this structure).

Details

Redox score ?
84
PDB code
6sa4
Structure name
salsa / dmbt1 / gp340 srcr domain 1
Structure deposition date
2019-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
140
Residue number B
1739
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 140 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1739 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 140 and 201 (1031 and 1092 respectively in this structure).

Details

Redox score ?
84
PDB code
6sa5
Structure name
salsa / dmbt1 / gp340 srcr domain 8
Structure deposition date
2019-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
140
Residue number B
201
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 140 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 111 and 145.

Details

Redox score ?
83
PDB code
6sa4
Structure name
salsa / dmbt1 / gp340 srcr domain 1
Structure deposition date
2019-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
111
Residue number B
145
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 111 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 127 and 191.

Details

Redox score ?
82
PDB code
6sa4
Structure name
salsa / dmbt1 / gp340 srcr domain 1
Structure deposition date
2019-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
127
Residue number B
191
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 127 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 127 and 583 (1018 and 1082 respectively in this structure).

Details

Redox score ?
82
PDB code
6san
Structure name
salsa / dmbt1 / gp340 srcr domain 8 soaked in calcium and magnesium
Structure deposition date
2019-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
127
Residue number B
583
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 127 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 583 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 145 and 201 (1036 and 1092 respectively in this structure).

Details

Redox score ?
71
PDB code
6sa5
Structure name
salsa / dmbt1 / gp340 srcr domain 8
Structure deposition date
2019-07-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
145
Residue number B
201
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 145 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 145 and 1739 (1036 and 1092 respectively in this structure).

Details

Redox score ?
69
PDB code
6san
Structure name
salsa / dmbt1 / gp340 srcr domain 8 soaked in calcium and magnesium
Structure deposition date
2019-07-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
145
Residue number B
1739
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 145 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1739 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 372 and 1739 (1002 and 1092 respectively in this structure).

Details

Redox score ?
65
PDB code
6san
Structure name
salsa / dmbt1 / gp340 srcr domain 8 soaked in calcium and magnesium
Structure deposition date
2019-07-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
372
Residue number B
1739
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 372 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1739 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 111 and 1739 (111 and 201 respectively in this structure).

Details

Redox score ?
64
PDB code
6sa4
Structure name
salsa / dmbt1 / gp340 srcr domain 1
Structure deposition date
2019-07-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
111
Residue number B
1739
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 111 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1739 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 372 and 201 (1002 and 1092 respectively in this structure).

Details

Redox score ?
63
PDB code
6sa5
Structure name
salsa / dmbt1 / gp340 srcr domain 8
Structure deposition date
2019-07-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
372
Residue number B
201
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 372 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 140 and 145 (1031 and 1036 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6san
Structure name
salsa / dmbt1 / gp340 srcr domain 8 soaked in calcium and magnesium
Structure deposition date
2019-07-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
140
Residue number B
145
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 140 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 372 and 140 (1002 and 1031 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6san
Structure name
salsa / dmbt1 / gp340 srcr domain 8 soaked in calcium and magnesium
Structure deposition date
2019-07-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
372
Residue number B
140
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 372 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 140 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deleted in malignant brain tumors 1 protein between cysteines 111 and 140. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6sa4
Structure name
salsa / dmbt1 / gp340 srcr domain 1
Structure deposition date
2019-07-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGM3
Residue number A
111
Residue number B
140
Peptide name
Deleted in malignant brain tumors 1 protein

Ligandability

Cysteine 111 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 140 of Deleted in malignant brain tumors 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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