ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CMRF35-like molecule 8

Intramolecular
Cysteine 50 and cysteine 58
Cysteine 36 and cysteine 103
Cysteine 50 and cysteine 103
Cysteine 58 and cysteine 103
A redox-regulated disulphide may form within CMRF35-like molecule 8 between cysteines 50 and 58 (33 and 41 respectively in this structure).

Details

Redox score ?
85
PDB code
2q87
Structure name
the crystal structure of the human irp60 ectodomain
Structure deposition date
2007-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGN4
Residue number A
50
Residue number B
58
Peptide name
CMRF35-like molecule 8

Ligandability

Cysteine 50 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CMRF35-like molecule 8 between cysteines 36 and 103 (19 and 86 respectively in this structure).

Details

Redox score ?
79
PDB code
2q87
Structure name
the crystal structure of the human irp60 ectodomain
Structure deposition date
2007-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGN4
Residue number A
36
Residue number B
103
Peptide name
CMRF35-like molecule 8

Ligandability

Cysteine 36 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CMRF35-like molecule 8 between cysteines 50 and 103 (33 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2q87
Structure name
the crystal structure of the human irp60 ectodomain
Structure deposition date
2007-06-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGN4
Residue number A
50
Residue number B
103
Peptide name
CMRF35-like molecule 8

Ligandability

Cysteine 50 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CMRF35-like molecule 8 between cysteines 58 and 103 (41 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2q87
Structure name
the crystal structure of the human irp60 ectodomain
Structure deposition date
2007-06-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UGN4
Residue number A
58
Residue number B
103
Peptide name
CMRF35-like molecule 8

Ligandability

Cysteine 58 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of CMRF35-like molecule 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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