ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Poly [ADP-ribose] polymerase 2

Intramolecular
Cysteine 264 and cysteine 278
Cysteine 246 and cysteine 367
A redox-regulated disulphide may form within Poly [ADP-ribose] polymerase 2 between cysteines 264 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1gs0
Structure name
crystal structure of the catalytic fragment of murine poly (adp-ribose) polymerase-2
Structure deposition date
2001-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
29
Peptide accession
O88554
Residue number A
264
Residue number B
278
Peptide name
Poly [ADP-ribose] polymerase 2

Ligandability

Cysteine 264 of Poly [ADP-ribose] polymerase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Poly [ADP-ribose] polymerase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly [ADP-ribose] polymerase 2 between cysteines 246 and 367 (233 and 354 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6x0m
Structure name
bridging of double-strand dna break activates parp2/hpf1 to modify chromatin
Structure deposition date
2020-05-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
80
Peptide accession
Q9UGN5
Residue number A
246
Residue number B
367
Peptide name
Poly [ADP-ribose] polymerase 2

Ligandability

Cysteine 246 of Poly [ADP-ribose] polymerase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 367 of Poly [ADP-ribose] polymerase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: