ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Large neutral amino acids transporter small subunit 2

Intermolecular
Cysteine 210 of 4F2 cell-surface antigen heavy chain and cysteine 154
Intramolecular
Cysteine 177 and cysteine 491
Cysteine 177 and cysteine 372
A redox-regulated disulphide may form between cysteine 210 of 4F2 cell-surface antigen heavy chain and cysteine 154 of Large neutral amino acids transporter small subunit 2 (211 and 154 respectively in this structure).

Details

Redox score ?
87
PDB code
7cmi
Structure name
the lat2-4f2hc complex in complex with leucine
Structure deposition date
2020-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
4F2 cell-surface antigen heavy chain
Peptide B name
Large neutral amino acids transporter small subunit 2
Peptide A accession
J3KPF3
Peptide B accession
Q9UHI5
Peptide A residue number
210
Peptide B residue number
154

Ligandability

Cysteine 210 of 4F2 cell-surface antigen heavy chain

Cysteine 154 of Large neutral amino acids transporter small subunit 2

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 2 between cysteines 177 and 491. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7b00
Structure name
human lat2-4f2hc complex in the apo-state
Structure deposition date
2020-11-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
72
Peptide accession
Q9UHI5
Residue number A
177
Residue number B
491
Peptide name
Large neutral amino acids transporter small subunit 2

Ligandability

Cysteine 177 of Large neutral amino acids transporter small subunit 2

Cysteine 491 of Large neutral amino acids transporter small subunit 2

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 2 between cysteines 177 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
8a6l
Structure name
human 4f2hc-lat2 heterodimeric amino acid transporter in complex with anticalin d11vs
Structure deposition date
2022-06-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
84
Peptide accession
Q9UHI5
Residue number A
177
Residue number B
372
Peptide name
Large neutral amino acids transporter small subunit 2

Ligandability

Cysteine 177 of Large neutral amino acids transporter small subunit 2

Cysteine 372 of Large neutral amino acids transporter small subunit 2

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